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Characteristics and prognosis of healthy severe obesity (HSO) subjects - The Malmo Preventive Project

Tremmel, Maximilian LU ; Lyssenko, Valeriya LU ; Zöller, Bengt LU ; Engström, Gunnar LU ; Magnusson, Martin LU ; Melander, Olle LU ; Nilsson, Peter M. LU and Bachus, Erasmus LU (2018) In Obesity Medicine 11. p.6-12
Abstract

Background: The characteristics and prognosis of healthy obesity (HO) still remain unclear. We aimed to examine the characteristics of healthy severe obesity (HSO), defined by a novel approach, with a focus on self-reported physical activity (PA) and a genetic risk score for type 2 diabetes (GRS DM2). Methods: A cross-sectional analysis was carried out in a subsample of severly obese subjects (BMI≥35 kg/m2; n = 809) selected from the population-based Malmo Preventive Project (MPP). Subjects with HSO (n = 57) were defined by having no records of hospitalisation in the Swedish Hospital Discharge Register during a time period of 33.4 ± 3.9 years between baseline (1974–1992) and the end of follow-up (31st of December 2014). They... (More)

Background: The characteristics and prognosis of healthy obesity (HO) still remain unclear. We aimed to examine the characteristics of healthy severe obesity (HSO), defined by a novel approach, with a focus on self-reported physical activity (PA) and a genetic risk score for type 2 diabetes (GRS DM2). Methods: A cross-sectional analysis was carried out in a subsample of severly obese subjects (BMI≥35 kg/m2; n = 809) selected from the population-based Malmo Preventive Project (MPP). Subjects with HSO (n = 57) were defined by having no records of hospitalisation in the Swedish Hospital Discharge Register during a time period of 33.4 ± 3.9 years between baseline (1974–1992) and the end of follow-up (31st of December 2014). They were compared to subjects with unhealthy severe obesity (USO; n = 752), as well as age- and sex-matched non-obese controls (n = 1618). Results: Subjects with HSO had a significantly lower GRS DM2 (HSO 40.4 ± 3.7 vs. USO 41.8 ± 3.8, p = 0.007). Compared to subjects with USO, the HSO subjects reported significantly more leisure-time physical activity, PA (p = 0.016). There were no significant differences between HSO and USO subjects in the distribution of fat mass or obesity-associated gene phenotypes (FTO gene; variant rs9939609; p = 0.8). Conclusion: Higher PA and lower GRS DM2 might be protective factors against all-cause hospitalisation in subjects with severe obesity. These findings support the concept of HO being fat but fit. Still, it remains unclear whether higher PA is causally related to HSO, and which role environmental factors such as PA play in the interaction with genetic factors such as GRS DM2.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes, Epidemiology, Genetic risk score, Healthy severe obesity, Hospitalisation, Obesity, Physical activity
in
Obesity Medicine
volume
11
pages
7 pages
publisher
Elsevier Ltd
external identifiers
  • scopus:85049342888
ISSN
2451-8476
DOI
10.1016/j.obmed.2018.06.005
language
English
LU publication?
yes
id
1f2db2d4-ae75-4cce-819a-b76d7f99c87c
date added to LUP
2018-07-12 13:41:02
date last changed
2018-11-21 21:40:44
@article{1f2db2d4-ae75-4cce-819a-b76d7f99c87c,
  abstract     = {<p>Background: The characteristics and prognosis of healthy obesity (HO) still remain unclear. We aimed to examine the characteristics of healthy severe obesity (HSO), defined by a novel approach, with a focus on self-reported physical activity (PA) and a genetic risk score for type 2 diabetes (GRS DM2). Methods: A cross-sectional analysis was carried out in a subsample of severly obese subjects (BMI≥35 kg/m<sup>2</sup>; n = 809) selected from the population-based Malmo Preventive Project (MPP). Subjects with HSO (n = 57) were defined by having no records of hospitalisation in the Swedish Hospital Discharge Register during a time period of 33.4 ± 3.9 years between baseline (1974–1992) and the end of follow-up (31st of December 2014). They were compared to subjects with unhealthy severe obesity (USO; n = 752), as well as age- and sex-matched non-obese controls (n = 1618). Results: Subjects with HSO had a significantly lower GRS DM2 (HSO 40.4 ± 3.7 vs. USO 41.8 ± 3.8, p = 0.007). Compared to subjects with USO, the HSO subjects reported significantly more leisure-time physical activity, PA (p = 0.016). There were no significant differences between HSO and USO subjects in the distribution of fat mass or obesity-associated gene phenotypes (FTO gene; variant rs9939609; p = 0.8). Conclusion: Higher PA and lower GRS DM2 might be protective factors against all-cause hospitalisation in subjects with severe obesity. These findings support the concept of HO being fat but fit. Still, it remains unclear whether higher PA is causally related to HSO, and which role environmental factors such as PA play in the interaction with genetic factors such as GRS DM2.</p>},
  author       = {Tremmel, Maximilian and Lyssenko, Valeriya and Zöller, Bengt and Engström, Gunnar and Magnusson, Martin and Melander, Olle and Nilsson, Peter M. and Bachus, Erasmus},
  issn         = {2451-8476},
  keyword      = {Diabetes,Epidemiology,Genetic risk score,Healthy severe obesity,Hospitalisation,Obesity,Physical activity},
  language     = {eng},
  month        = {09},
  pages        = {6--12},
  publisher    = {Elsevier Ltd},
  series       = {Obesity Medicine},
  title        = {Characteristics and prognosis of healthy severe obesity (HSO) subjects - The Malmo Preventive Project},
  url          = {http://dx.doi.org/10.1016/j.obmed.2018.06.005},
  volume       = {11},
  year         = {2018},
}