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Patch testing with a new composition of mercapto mix : A multicentre study by the Swedish contact dermatitis research group

Engfeldt, Malin LU ; Isaksson, Marléne LU ; Glas, Bo ; Hagvall, Lina ; Löfnertz Petersson, Anna ; Matura, Mihaly ; Stenberg, Berndt ; Svedman, Cecilia LU and Bruze, Magnus LU (2019) In Acta Dermato-Venereologica 99(11). p.960-963
Abstract

This study investigated whether more patients with contact allergies were detected by patch testing with mercapto mix with a higher concentration of 2-mercaptobenzothiazolinone (MBT) than the commonly used mercapto mix. A total of 3,143 dermatitis patients in 5 Swedish dermatology departments were patch- tested with 3 mercapto test preparations: MBT 2.0% petrolatum (pet.); mercapto mix 2.0% pet.; and mercapto mix 3.5% pet. Positive reactions to these mercapto mixes varied between 0–0.50%, 0–0.93%, and 0–1.4%, respectively, in the 5 centres. Numerically, mercapto mix 3.5% pet. detected all positive patients and more patch-test positive patients than did the 2 other substances, but the difference was not statistically significant. The... (More)

This study investigated whether more patients with contact allergies were detected by patch testing with mercapto mix with a higher concentration of 2-mercaptobenzothiazolinone (MBT) than the commonly used mercapto mix. A total of 3,143 dermatitis patients in 5 Swedish dermatology departments were patch- tested with 3 mercapto test preparations: MBT 2.0% petrolatum (pet.); mercapto mix 2.0% pet.; and mercapto mix 3.5% pet. Positive reactions to these mercapto mixes varied between 0–0.50%, 0–0.93%, and 0–1.4%, respectively, in the 5 centres. Numerically, mercapto mix 3.5% pet. detected all positive patients and more patch-test positive patients than did the 2 other substances, but the difference was not statistically significant. The authors recommend replacing mercapto mix 2.0% pet. in the Swedish baseline series with mercapto mix 3.5% pet., since the latter also detected those patients who would have been missed because MBT 2.0% is not included in the Swedish baseline series.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
2-mercaptobenzothiazole, Allergic contact dermatitis, Contact allergy, Delayed hypersensitivity, Mercapto mix, Rubber
in
Acta Dermato-Venereologica
volume
99
issue
11
pages
4 pages
publisher
Medical Journals Limited
external identifiers
  • scopus:85073461735
  • pmid:31240321
ISSN
0001-5555
DOI
10.2340/00015555-3249
language
English
LU publication?
yes
id
1f2dc0e1-8f2e-4c4d-9820-05f897a978ea
date added to LUP
2019-10-28 15:02:41
date last changed
2025-10-17 12:21:49
@article{1f2dc0e1-8f2e-4c4d-9820-05f897a978ea,
  abstract     = {{<p>This study investigated whether more patients with contact allergies were detected by patch testing with mercapto mix with a higher concentration of 2-mercaptobenzothiazolinone (MBT) than the commonly used mercapto mix. A total of 3,143 dermatitis patients in 5 Swedish dermatology departments were patch- tested with 3 mercapto test preparations: MBT 2.0% petrolatum (pet.); mercapto mix 2.0% pet.; and mercapto mix 3.5% pet. Positive reactions to these mercapto mixes varied between 0–0.50%, 0–0.93%, and 0–1.4%, respectively, in the 5 centres. Numerically, mercapto mix 3.5% pet. detected all positive patients and more patch-test positive patients than did the 2 other substances, but the difference was not statistically significant. The authors recommend replacing mercapto mix 2.0% pet. in the Swedish baseline series with mercapto mix 3.5% pet., since the latter also detected those patients who would have been missed because MBT 2.0% is not included in the Swedish baseline series.</p>}},
  author       = {{Engfeldt, Malin and Isaksson, Marléne and Glas, Bo and Hagvall, Lina and Löfnertz Petersson, Anna and Matura, Mihaly and Stenberg, Berndt and Svedman, Cecilia and Bruze, Magnus}},
  issn         = {{0001-5555}},
  keywords     = {{2-mercaptobenzothiazole; Allergic contact dermatitis; Contact allergy; Delayed hypersensitivity; Mercapto mix; Rubber}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{960--963}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Patch testing with a new composition of mercapto mix : A multicentre study by the Swedish contact dermatitis research group}},
  url          = {{http://dx.doi.org/10.2340/00015555-3249}},
  doi          = {{10.2340/00015555-3249}},
  volume       = {{99}},
  year         = {{2019}},
}