Alveolar epithelial clearance of protein
(1996) In Journal of Applied Physiology 80(5). p.1431-1445- Abstract
Substantial progress has been made in understanding the rate, the pathways, and the mechanisms regulating alveolar protein removal from the uninjured lung. Whole animal studies and cellular studies have demonstrated that the majority of alveolar epithelial protein clearance occurs by passive nondegradative diffusional pathways. Some evidence, however, has been recently presented that alveolar epithelial cells express an albumin-binding receptor as well as a polymeric immunoglobulin receptor, both of which might be important for alveolar epithelial clearance of protein. However, the contribution of these receptors requires further studies. Little is known about alveolar clearance of protein during pathological conditions; further studies... (More)
Substantial progress has been made in understanding the rate, the pathways, and the mechanisms regulating alveolar protein removal from the uninjured lung. Whole animal studies and cellular studies have demonstrated that the majority of alveolar epithelial protein clearance occurs by passive nondegradative diffusional pathways. Some evidence, however, has been recently presented that alveolar epithelial cells express an albumin-binding receptor as well as a polymeric immunoglobulin receptor, both of which might be important for alveolar epithelial clearance of protein. However, the contribution of these receptors requires further studies. Little is known about alveolar clearance of protein during pathological conditions; further studies are required to determine the roles of the different cell types in the lung for removal of protein from the alveolar spaces of the lung. Alveolar macrophages are likely to play an important role in the degradation and removal of insoluble protein from the distal air spaces after acute lung injury. In conclusion, the present data suggest that most proteins and peptides deposited on the epithelial surfaces in the distal air spaces are cleared as intact molecules, predominantly via paracellular routes. The contribution of pinocytic processes appear to be of minor importance for translocation of bulk quantities of proteins or peptides across the alveolar epithelium.
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- author
- Folkesson, Hans G. LU ; Matthay, Michael A. ; Weström, Björn R. LU ; Kim, Kwang J. ; Karlsson, Börje W. LU and Hastings, Randolph H.
- organization
- publishing date
- 1996-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- absorption, acute lung injury, aerosol, alveolar epithelium, diffusion, drug delivery, endocytosis, epithelial permeability, intratracheal instillation, macromolecules, molecular weight, pulmonary edema, transcytosis, uptake
- in
- Journal of Applied Physiology
- volume
- 80
- issue
- 5
- pages
- 15 pages
- publisher
- American Physiological Society
- external identifiers
-
- scopus:0029963274
- pmid:8727524
- ISSN
- 8750-7587
- DOI
- 10.1152/jappl.1996.80.5.1431
- language
- English
- LU publication?
- yes
- id
- 1f440da0-e88f-4a62-90ef-fce823961d13
- date added to LUP
- 2024-12-05 15:21:38
- date last changed
- 2025-07-04 09:10:31
@article{1f440da0-e88f-4a62-90ef-fce823961d13,
abstract = {{<p>Substantial progress has been made in understanding the rate, the pathways, and the mechanisms regulating alveolar protein removal from the uninjured lung. Whole animal studies and cellular studies have demonstrated that the majority of alveolar epithelial protein clearance occurs by passive nondegradative diffusional pathways. Some evidence, however, has been recently presented that alveolar epithelial cells express an albumin-binding receptor as well as a polymeric immunoglobulin receptor, both of which might be important for alveolar epithelial clearance of protein. However, the contribution of these receptors requires further studies. Little is known about alveolar clearance of protein during pathological conditions; further studies are required to determine the roles of the different cell types in the lung for removal of protein from the alveolar spaces of the lung. Alveolar macrophages are likely to play an important role in the degradation and removal of insoluble protein from the distal air spaces after acute lung injury. In conclusion, the present data suggest that most proteins and peptides deposited on the epithelial surfaces in the distal air spaces are cleared as intact molecules, predominantly via paracellular routes. The contribution of pinocytic processes appear to be of minor importance for translocation of bulk quantities of proteins or peptides across the alveolar epithelium.</p>}},
author = {{Folkesson, Hans G. and Matthay, Michael A. and Weström, Björn R. and Kim, Kwang J. and Karlsson, Börje W. and Hastings, Randolph H.}},
issn = {{8750-7587}},
keywords = {{absorption; acute lung injury; aerosol; alveolar epithelium; diffusion; drug delivery; endocytosis; epithelial permeability; intratracheal instillation; macromolecules; molecular weight; pulmonary edema; transcytosis; uptake}},
language = {{eng}},
number = {{5}},
pages = {{1431--1445}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{Alveolar epithelial clearance of protein}},
url = {{http://dx.doi.org/10.1152/jappl.1996.80.5.1431}},
doi = {{10.1152/jappl.1996.80.5.1431}},
volume = {{80}},
year = {{1996}},
}