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Repairing the brain : Gene therapy

Bjorklund, Tomas LU (2018) In Journal of Parkinson's Disease 8(s1). p.123-130
Abstract

In vivo gene therapy for neurodegenerative disorders has turned out to be a formidable challenge. It is a field not much older than twenty years, but we were many who would have predicted a much easier path towards the clinic using this treatment modality. For Parkinson's disease patients, this has meant a frustrating wait, seeing many promising therapies being forgotten after a few pre-clinical proof-of-concept studies. The reasons for this are both scientific and economical. However, this is slowly but surely changing and over the next two decades we will see a very exciting development in this field. In a foreseeable future, gene therapy will be a very natural component of many clinical therapies, not least in Parkinson's disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Clinical trial, Dependovirus, Gene editing, Genetic therapy, Neuroprotection, Parkinson's disease, Rejuvenation
in
Journal of Parkinson's Disease
volume
8
issue
s1
pages
123 - 130
publisher
IOS Press
external identifiers
  • scopus:85058849634
ISSN
1877-7171
DOI
10.3233/JPD-181485
language
English
LU publication?
yes
id
1f4d64d9-6866-4d69-a503-9255deefb78b
date added to LUP
2019-01-08 12:39:40
date last changed
2019-02-20 11:42:01
@article{1f4d64d9-6866-4d69-a503-9255deefb78b,
  abstract     = {<p>In vivo gene therapy for neurodegenerative disorders has turned out to be a formidable challenge. It is a field not much older than twenty years, but we were many who would have predicted a much easier path towards the clinic using this treatment modality. For Parkinson's disease patients, this has meant a frustrating wait, seeing many promising therapies being forgotten after a few pre-clinical proof-of-concept studies. The reasons for this are both scientific and economical. However, this is slowly but surely changing and over the next two decades we will see a very exciting development in this field. In a foreseeable future, gene therapy will be a very natural component of many clinical therapies, not least in Parkinson's disease.</p>},
  author       = {Bjorklund, Tomas},
  issn         = {1877-7171},
  keyword      = {Clinical trial,Dependovirus,Gene editing,Genetic therapy,Neuroprotection,Parkinson's disease,Rejuvenation},
  language     = {eng},
  number       = {s1},
  pages        = {123--130},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Repairing the brain : Gene therapy},
  url          = {http://dx.doi.org/10.3233/JPD-181485},
  volume       = {8},
  year         = {2018},
}