Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer

Reynisdottir, Inga ; Arason, Adalgeir ; Einarsdottir, Berglind ; Gunnarsson, Haukur ; Staaf, Johan LU orcid ; Vallon-Christersson, Johan LU orcid ; Jönsson, Göran B LU ; Ringnér, Markus LU orcid ; Agnarsson, Bjarni and Olafsdottir, Kristrun , et al. (2013) In Cancer Medicine 2(4). p.437-446
Abstract
Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped in 359 tumors, and gene expression data from 577 tumors (359 tumors included) were correlated with CNA, clinical–pathological factors, and protein expression (39 tumors). 8p12-p11 was amplified in 11.4% of tumors. The smallest region of amplification harbored one full-length gene, ZNF703. ZNF703 mRNA expression was significantly higher in estrogen... (More)
Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped in 359 tumors, and gene expression data from 577 tumors (359 tumors included) were correlated with CNA, clinical–pathological factors, and protein expression (39 tumors). 8p12-p11 was amplified in 11.4% of tumors. The smallest region of amplification harbored one full-length gene, ZNF703. ZNF703 mRNA expression was significantly higher in estrogen receptor (ER)-positive than ER-negative tumors (P = 2 × 10−16), a reflection of high expression in luminal tumors. Forty-eight percent of tumors with ZNF703 amplification were luminal B tumors in which the best correlation between DNA copy number and mRNA was seen (P = 1.2 × 10−7) as well as correlation between mRNA and protein expression (P = 0.02). High ZNF703 mRNA correlated with poor survival in patients with ER-positive luminal B tumors (log rank P = 0.04). Furthermore, high ZNF703 mRNA expression correlated with poor outcome in patients with ZNF703 copy number neutral, ER-positive, luminal B tumors (log rank P = 0.004). The results support ZNF703 as the driver gene of the 8p12 amplification and suggest that independent of amplification, high expression of the gene affects prognosis in luminal B tumors. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ZNF703, tumor progression, prognosis, luminal tumors, ER positive, 8p12-p11 amplification
in
Cancer Medicine
volume
2
issue
4
pages
437 - 446
publisher
Wiley-Blackwell
external identifiers
  • scopus:84902110153
ISSN
2045-7634
DOI
10.1002/cam4.88
language
English
LU publication?
yes
id
1f77e7fc-8508-4593-91bc-023f2927e9d8 (old id 4930246)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/?term=24156016
date added to LUP
2016-04-01 13:45:18
date last changed
2022-01-27 20:53:56
@article{1f77e7fc-8508-4593-91bc-023f2927e9d8,
  abstract     = {{Amplification of 8p12-p11 is relatively common in breast cancer and several genes within the region have been suggested to affect breast tumor progression. The aim of the study was to map the amplified 8p12-p11 region in a large set of breast tumors in an effort to identify the genetic driver and to explore its impact on tumor progression and prognosis. Copy number alterations (CNAs) were mapped in 359 tumors, and gene expression data from 577 tumors (359 tumors included) were correlated with CNA, clinical–pathological factors, and protein expression (39 tumors). 8p12-p11 was amplified in 11.4% of tumors. The smallest region of amplification harbored one full-length gene, ZNF703. ZNF703 mRNA expression was significantly higher in estrogen receptor (ER)-positive than ER-negative tumors (P = 2 × 10−16), a reflection of high expression in luminal tumors. Forty-eight percent of tumors with ZNF703 amplification were luminal B tumors in which the best correlation between DNA copy number and mRNA was seen (P = 1.2 × 10−7) as well as correlation between mRNA and protein expression (P = 0.02). High ZNF703 mRNA correlated with poor survival in patients with ER-positive luminal B tumors (log rank P = 0.04). Furthermore, high ZNF703 mRNA expression correlated with poor outcome in patients with ZNF703 copy number neutral, ER-positive, luminal B tumors (log rank P = 0.004). The results support ZNF703 as the driver gene of the 8p12 amplification and suggest that independent of amplification, high expression of the gene affects prognosis in luminal B tumors.}},
  author       = {{Reynisdottir, Inga and Arason, Adalgeir and Einarsdottir, Berglind and Gunnarsson, Haukur and Staaf, Johan and Vallon-Christersson, Johan and Jönsson, Göran B and Ringnér, Markus and Agnarsson, Bjarni and Olafsdottir, Kristrun and Fagerholm, Rainer and Einarsdottir, Thorbjorg and Johannesdottir, Gudrun and Johannsson, Oskar Thor and Nevanlinna, Heli and Borg, Åke and Barkardottir, Rosa}},
  issn         = {{2045-7634}},
  keywords     = {{ZNF703; tumor progression; prognosis; luminal tumors; ER positive; 8p12-p11 amplification}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{437--446}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cancer Medicine}},
  title        = {{High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer}},
  url          = {{https://lup.lub.lu.se/search/files/3568915/8625933}},
  doi          = {{10.1002/cam4.88}},
  volume       = {{2}},
  year         = {{2013}},
}