Advanced

Swedish national guideline for prevention and treatment of neonatal hypoglycaemia in newborn infants with gestational age ≥35 weeks

Wackernagel, Dirk ; Gustafsson, Anna ; Edstedt Bonamy, Anna Karin ; Reims, Annika ; Ahlsson, Fredrik LU ; Elfving, Maria LU ; Domellöf, Magnus and Hansen Pupp, Ingrid LU (2020) In Acta Paediatrica, International Journal of Paediatrics 109(1). p.31-44
Abstract

Aim: Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35 + 0 weeks. Methods: A PubMed search-based literature review was used to find actual and applicable evidence for all incorporated recommendations. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach was used for grading the evidence of the recommendations. Results: Recommendations for the prevention of neonatal hypoglycaemia were extended... (More)

Aim: Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35 + 0 weeks. Methods: A PubMed search-based literature review was used to find actual and applicable evidence for all incorporated recommendations. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach was used for grading the evidence of the recommendations. Results: Recommendations for the prevention of neonatal hypoglycaemia were extended and updated, focusing on promotion of breastfeeding as one prevention strategy. Oral dextrose gel as a novel supplemental therapy was incorporated in the treatment protocol. A new threshold-based screening and treatment protocol presented as a flow chart was developed. Conclusion: An updated and evidence-based national guideline for screening and treatment of neonatal hypoglycaemia will support standardised regimes, which may prevent hypoglycaemia and the risk for hypoglycaemia-related long-term sequelae.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breastfeeding, dextrose gel, guideline, hypoglycaemia, newborn infant
in
Acta Paediatrica, International Journal of Paediatrics
volume
109
issue
1
pages
31 - 44
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85071339419
  • pmid:31350926
ISSN
0803-5253
DOI
10.1111/apa.14955
language
English
LU publication?
yes
id
1f96e326-f092-4d02-bbdb-70d82f240fb3
date added to LUP
2019-09-03 08:21:06
date last changed
2020-01-28 13:53:13
@article{1f96e326-f092-4d02-bbdb-70d82f240fb3,
  abstract     = {<p>Aim: Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35 + 0 weeks. Methods: A PubMed search-based literature review was used to find actual and applicable evidence for all incorporated recommendations. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach was used for grading the evidence of the recommendations. Results: Recommendations for the prevention of neonatal hypoglycaemia were extended and updated, focusing on promotion of breastfeeding as one prevention strategy. Oral dextrose gel as a novel supplemental therapy was incorporated in the treatment protocol. A new threshold-based screening and treatment protocol presented as a flow chart was developed. Conclusion: An updated and evidence-based national guideline for screening and treatment of neonatal hypoglycaemia will support standardised regimes, which may prevent hypoglycaemia and the risk for hypoglycaemia-related long-term sequelae.</p>},
  author       = {Wackernagel, Dirk and Gustafsson, Anna and Edstedt Bonamy, Anna Karin and Reims, Annika and Ahlsson, Fredrik and Elfving, Maria and Domellöf, Magnus and Hansen Pupp, Ingrid},
  issn         = {0803-5253},
  language     = {eng},
  number       = {1},
  pages        = {31--44},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Swedish national guideline for prevention and treatment of neonatal hypoglycaemia in newborn infants with gestational age ≥35 weeks},
  url          = {http://dx.doi.org/10.1111/apa.14955},
  doi          = {10.1111/apa.14955},
  volume       = {109},
  year         = {2020},
}