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The non-haemostatic role of platelets in systemic lupus erythematosus

Linge, Petrus LU ; Fortin, Paul R.; Lood, Christian LU ; Bengtsson, Anders A. LU and Boilard, Eric (2018) In Nature Reviews Rheumatology 14(4). p.195-213
Abstract

Dysregulation of lymphocyte function, accumulation of autoantibodies and defective clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic lupus erythematosus (SLE). Moreover, it is now evident that an intricate interplay between the adaptive and innate immune systems contributes to the pathogenesis of SLE, ultimately resulting in chronic inflammation and organ damage. Platelets circulate in the blood and are chiefly recognized for their role in the prevention of bleeding and promotion of haemostasis; however, accumulating evidence points to a role for platelets in both adaptive and innate immunity. Through a broad repertoire of receptors, platelets respond promptly to immune complexes, complement and... (More)

Dysregulation of lymphocyte function, accumulation of autoantibodies and defective clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic lupus erythematosus (SLE). Moreover, it is now evident that an intricate interplay between the adaptive and innate immune systems contributes to the pathogenesis of SLE, ultimately resulting in chronic inflammation and organ damage. Platelets circulate in the blood and are chiefly recognized for their role in the prevention of bleeding and promotion of haemostasis; however, accumulating evidence points to a role for platelets in both adaptive and innate immunity. Through a broad repertoire of receptors, platelets respond promptly to immune complexes, complement and damage-associated molecular patterns, and represent a major reservoir of immunomodulatory molecules in the circulation. Furthermore, evidence suggests that platelets are activated in patients with SLE, and that they could contribute to the circulatory autoantigenic load through the release of microparticles and mitochondrial antigens. Herein, we highlight how platelets contribute to the immune response and review evidence implicating platelets in the pathogenesis of SLE.

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organization
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type
Contribution to journal
publication status
published
subject
in
Nature Reviews Rheumatology
volume
14
issue
4
pages
195 - 213
publisher
Nature Publishing Group
external identifiers
  • scopus:85044224421
ISSN
1759-4790
DOI
10.1038/nrrheum.2018.38
language
English
LU publication?
yes
id
1fb2aab6-5016-4889-b245-38356dd6c199
date added to LUP
2018-04-03 16:09:14
date last changed
2019-09-17 04:29:08
@article{1fb2aab6-5016-4889-b245-38356dd6c199,
  abstract     = {<p>Dysregulation of lymphocyte function, accumulation of autoantibodies and defective clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic lupus erythematosus (SLE). Moreover, it is now evident that an intricate interplay between the adaptive and innate immune systems contributes to the pathogenesis of SLE, ultimately resulting in chronic inflammation and organ damage. Platelets circulate in the blood and are chiefly recognized for their role in the prevention of bleeding and promotion of haemostasis; however, accumulating evidence points to a role for platelets in both adaptive and innate immunity. Through a broad repertoire of receptors, platelets respond promptly to immune complexes, complement and damage-associated molecular patterns, and represent a major reservoir of immunomodulatory molecules in the circulation. Furthermore, evidence suggests that platelets are activated in patients with SLE, and that they could contribute to the circulatory autoantigenic load through the release of microparticles and mitochondrial antigens. Herein, we highlight how platelets contribute to the immune response and review evidence implicating platelets in the pathogenesis of SLE.</p>},
  author       = {Linge, Petrus and Fortin, Paul R. and Lood, Christian and Bengtsson, Anders A. and Boilard, Eric},
  issn         = {1759-4790},
  language     = {eng},
  month        = {03},
  number       = {4},
  pages        = {195--213},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Rheumatology},
  title        = {The non-haemostatic role of platelets in systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1038/nrrheum.2018.38},
  volume       = {14},
  year         = {2018},
}