Advanced

Blood parasites shape extreme major histocompatibility complex diversity in a migratory passerine

Biedrzycka, Aleksandra; Bielański, Wojciech; Ćmiel, Adam; Solarz, Wojciech; Zajac, Tadeusz; Migalska, Magdalena; Sebastian, Alvaro; Westerdahl, Helena LU and Radwan, Jacek (2018) In Molecular Ecology 27(11).
Abstract

Pathogens are one of the main forces driving the evolution and maintenance of the highly polymorphic genes of the vertebrate major histocompatibility complex (MHC). Although MHC proteins are crucial in pathogen recognition, it is still poorly understood how pathogen-mediated selection promotes and maintains MHC diversity, and especially so in host species with highly duplicated MHC genes. Sedge warblers (Acrocephalus schoenobaenus) have highly duplicated MHC genes, and using data from high-throughput MHC genotyping, we were able to investigate to what extent avian malaria parasites explain temporal MHC class I supertype fluctuations in a long-term study population. We investigated infection status and infection intensities of two... (More)

Pathogens are one of the main forces driving the evolution and maintenance of the highly polymorphic genes of the vertebrate major histocompatibility complex (MHC). Although MHC proteins are crucial in pathogen recognition, it is still poorly understood how pathogen-mediated selection promotes and maintains MHC diversity, and especially so in host species with highly duplicated MHC genes. Sedge warblers (Acrocephalus schoenobaenus) have highly duplicated MHC genes, and using data from high-throughput MHC genotyping, we were able to investigate to what extent avian malaria parasites explain temporal MHC class I supertype fluctuations in a long-term study population. We investigated infection status and infection intensities of two different strains of Haemoproteus, that is avian malaria parasites that are known to have significant fitness consequences in sedge warblers. We found that prevalence of avian malaria in carriers of specific MHC class I supertypes was a significant predictor of their frequency changes between years. This finding suggests that avian malaria infections partly drive the temporal fluctuations of the MHC class I supertypes. Furthermore, we found that individuals with a large number of different supertypes had higher resistance to avian malaria, but there was no evidence for an optimal MHC class I diversity. Thus, the two studied malaria parasite strains appear to select for a high MHC class I supertype diversity. Such selection may explain the maintenance of the extremely high number of MHC class I gene copies in sedge warblers and possibly also in other passerines where avian malaria is a common disease.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acrocephalus schoenobaenus, Allele frequency changes, Avian malaria, Balancing selection, Copy number variation, Major histocompatibility complex diversity, Sedge warbler
in
Molecular Ecology
volume
27
issue
11
publisher
Wiley-Blackwell
external identifiers
  • scopus:85047461852
ISSN
0962-1083
DOI
10.1111/mec.14592
language
English
LU publication?
yes
id
1fc78f6f-f6bd-4a94-a05f-a0f3e0c8e2d5
date added to LUP
2018-06-07 10:36:36
date last changed
2019-03-24 04:46:54
@article{1fc78f6f-f6bd-4a94-a05f-a0f3e0c8e2d5,
  abstract     = {<p>Pathogens are one of the main forces driving the evolution and maintenance of the highly polymorphic genes of the vertebrate major histocompatibility complex (MHC). Although MHC proteins are crucial in pathogen recognition, it is still poorly understood how pathogen-mediated selection promotes and maintains MHC diversity, and especially so in host species with highly duplicated MHC genes. Sedge warblers (Acrocephalus schoenobaenus) have highly duplicated MHC genes, and using data from high-throughput MHC genotyping, we were able to investigate to what extent avian malaria parasites explain temporal MHC class I supertype fluctuations in a long-term study population. We investigated infection status and infection intensities of two different strains of Haemoproteus, that is avian malaria parasites that are known to have significant fitness consequences in sedge warblers. We found that prevalence of avian malaria in carriers of specific MHC class I supertypes was a significant predictor of their frequency changes between years. This finding suggests that avian malaria infections partly drive the temporal fluctuations of the MHC class I supertypes. Furthermore, we found that individuals with a large number of different supertypes had higher resistance to avian malaria, but there was no evidence for an optimal MHC class I diversity. Thus, the two studied malaria parasite strains appear to select for a high MHC class I supertype diversity. Such selection may explain the maintenance of the extremely high number of MHC class I gene copies in sedge warblers and possibly also in other passerines where avian malaria is a common disease.</p>},
  author       = {Biedrzycka, Aleksandra and Bielański, Wojciech and Ćmiel, Adam and Solarz, Wojciech and Zajac, Tadeusz and Migalska, Magdalena and Sebastian, Alvaro and Westerdahl, Helena and Radwan, Jacek},
  issn         = {0962-1083},
  keyword      = {Acrocephalus schoenobaenus,Allele frequency changes,Avian malaria,Balancing selection,Copy number variation,Major histocompatibility complex diversity,Sedge warbler},
  language     = {eng},
  number       = {11},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Ecology},
  title        = {Blood parasites shape extreme major histocompatibility complex diversity in a migratory passerine},
  url          = {http://dx.doi.org/10.1111/mec.14592},
  volume       = {27},
  year         = {2018},
}