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Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile

Noren, T. ; Akerlund, T. ; Wullt, Marlene LU ; Burman, L. G. and Unemo, M. (2007) In Antimicrobial Agents and Chemotherapy 51(5). p.1840-1843
Abstract
In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Antimicrobial Agents and Chemotherapy
volume
51
issue
5
pages
1840 - 1843
publisher
American Society for Microbiology
external identifiers
  • wos:000246541500038
  • scopus:34248367707
ISSN
1098-6596
DOI
10.1128/AAC.01283-06
language
English
LU publication?
yes
id
1fe0b184-a5b6-415a-ac27-7d4bf16dfb92 (old id 659722)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17307985&dopt=Abstract
date added to LUP
2016-04-01 16:58:39
date last changed
2022-02-28 00:59:20
@article{1fe0b184-a5b6-415a-ac27-7d4bf16dfb92,
  abstract     = {{In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.}},
  author       = {{Noren, T. and Akerlund, T. and Wullt, Marlene and Burman, L. G. and Unemo, M.}},
  issn         = {{1098-6596}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1840--1843}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Antimicrobial Agents and Chemotherapy}},
  title        = {{Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile}},
  url          = {{http://dx.doi.org/10.1128/AAC.01283-06}},
  doi          = {{10.1128/AAC.01283-06}},
  volume       = {{51}},
  year         = {{2007}},
}