D-serine in the developing human central nervous system
(2006) In Annals of Neurology 60(4). p.476-480- Abstract
To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and... (More)
To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.
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- author
- Fuchs, Sabine A. ; Dorland, Lambertus ; De Sain-Van Der Velden, Monique G. ; Hendriks, Margriet ; Klomp, Leo W.J. ; Berger, Ruud and De Koning, Tom J. LU
- publishing date
- 2006-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Neurology
- volume
- 60
- issue
- 4
- pages
- 5 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:17068790
- scopus:33750585344
- ISSN
- 0364-5134
- DOI
- 10.1002/ana.20977
- language
- English
- LU publication?
- no
- id
- 1fe86cdb-b654-40d9-b13b-0f19e7f1a658
- date added to LUP
- 2020-03-03 19:01:56
- date last changed
- 2024-02-16 12:23:30
@article{1fe86cdb-b654-40d9-b13b-0f19e7f1a658,
abstract = {{<p>To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.</p>}},
author = {{Fuchs, Sabine A. and Dorland, Lambertus and De Sain-Van Der Velden, Monique G. and Hendriks, Margriet and Klomp, Leo W.J. and Berger, Ruud and De Koning, Tom J.}},
issn = {{0364-5134}},
language = {{eng}},
month = {{10}},
number = {{4}},
pages = {{476--480}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Annals of Neurology}},
title = {{D-serine in the developing human central nervous system}},
url = {{http://dx.doi.org/10.1002/ana.20977}},
doi = {{10.1002/ana.20977}},
volume = {{60}},
year = {{2006}},
}