Association of inflammatory mediators with frailty status in older adults : results from a systematic review and meta-analysis
(2020) In GeroScience 42(6). p.1451-1473- Abstract
Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. “Inflammaging”, an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and... (More)
Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. “Inflammaging”, an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146–56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.
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- author
- Marcos-Pérez, Diego ; Sánchez-Flores, María ; Proietti, Stefania ; Bonassi, Stefano ; Costa, Solange ; Teixeira, Joao Paulo ; Fernández-Tajes, Juan LU ; Pásaro, Eduardo ; Laffon, Blanca and Valdiglesias, Vanessa
- organization
- publishing date
- 2020-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-reactive protein, Frailty, Inflammaging, Interleukin 6, Older adults, Tumor necrosis factor alpha
- in
- GeroScience
- volume
- 42
- issue
- 6
- pages
- 23 pages
- publisher
- Springer
- external identifiers
-
- scopus:85089447116
- pmid:32803650
- ISSN
- 2509-2715
- DOI
- 10.1007/s11357-020-00247-4
- language
- English
- LU publication?
- yes
- id
- 1fee5149-9a61-449a-88b7-341add8f17d0
- date added to LUP
- 2020-08-25 12:47:48
- date last changed
- 2024-06-13 22:03:59
@article{1fee5149-9a61-449a-88b7-341add8f17d0,
abstract = {{<p>Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. “Inflammaging”, an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146–56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.</p>}},
author = {{Marcos-Pérez, Diego and Sánchez-Flores, María and Proietti, Stefania and Bonassi, Stefano and Costa, Solange and Teixeira, Joao Paulo and Fernández-Tajes, Juan and Pásaro, Eduardo and Laffon, Blanca and Valdiglesias, Vanessa}},
issn = {{2509-2715}},
keywords = {{C-reactive protein; Frailty; Inflammaging; Interleukin 6; Older adults; Tumor necrosis factor alpha}},
language = {{eng}},
number = {{6}},
pages = {{1451--1473}},
publisher = {{Springer}},
series = {{GeroScience}},
title = {{Association of inflammatory mediators with frailty status in older adults : results from a systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.1007/s11357-020-00247-4}},
doi = {{10.1007/s11357-020-00247-4}},
volume = {{42}},
year = {{2020}},
}