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Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

Borggren, Marie LU ; Repits, Johanna; Sterjovski, Jasminka; Uchtenhagen, Hannes; Churchill, Melissa J; Karlsson, Anders; Albert, Jan; Achour, Adnane; Gorry, Paul R and Fenyö, Eva Maria LU , et al. (2011) In PLoS ONE 6(6).
Abstract
Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.
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PLoS ONE
volume
6
issue
6
publisher
Public Library of Science
external identifiers
  • wos:000291734100005
  • pmid:21698221
  • scopus:79959229025
ISSN
1932-6203
DOI
10.1371/journal.pone.0020135
language
English
LU publication?
yes
id
70cf378e-3896-4b3b-92bd-2a00cd0012af (old id 2007819)
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http://www.ncbi.nlm.nih.gov/pubmed/21698221?dopt=Abstract
date added to LUP
2011-07-06 10:59:16
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2017-03-21 10:46:40
@article{70cf378e-3896-4b3b-92bd-2a00cd0012af,
  abstract     = {Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.},
  articleno    = {e20135},
  author       = {Borggren, Marie and Repits, Johanna and Sterjovski, Jasminka and Uchtenhagen, Hannes and Churchill, Melissa J and Karlsson, Anders and Albert, Jan and Achour, Adnane and Gorry, Paul R and Fenyö, Eva Maria and Jansson, Marianne},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0020135},
  volume       = {6},
  year         = {2011},
}