Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

Borggren, Marie LU ; Repits, Johanna ; Sterjovski, Jasminka ; Uchtenhagen, Hannes ; Churchill, Melissa J ; Karlsson, Anders ; Albert, Jan ; Achour, Adnane ; Gorry, Paul R and Fenyö, Eva Maria LU , et al. (2011) In PLoS ONE 6(6).
Abstract
Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
6
issue
6
article number
e20135
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000291734100005
  • pmid:21698221
  • scopus:79959229025
ISSN
1932-6203
DOI
10.1371/journal.pone.0020135
language
English
LU publication?
yes
id
70cf378e-3896-4b3b-92bd-2a00cd0012af (old id 2007819)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21698221?dopt=Abstract
date added to LUP
2016-04-04 09:18:40
date last changed
2021-10-06 03:22:33
@article{70cf378e-3896-4b3b-92bd-2a00cd0012af,
  abstract     = {Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.},
  author       = {Borggren, Marie and Repits, Johanna and Sterjovski, Jasminka and Uchtenhagen, Hannes and Churchill, Melissa J and Karlsson, Anders and Albert, Jan and Achour, Adnane and Gorry, Paul R and Fenyö, Eva Maria and Jansson, Marianne},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science (PLoS)},
  series       = {PLoS ONE},
  title        = {Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.},
  url          = {https://lup.lub.lu.se/search/files/5289400/2172652.pdf},
  doi          = {10.1371/journal.pone.0020135},
  volume       = {6},
  year         = {2011},
}