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Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

Mulinari, Shai LU and Häcker, Udo LU (2010) In Small GTPases 1(1). p.28-43
Abstract
The development of multicellular organisms is associated with extensive rearrangements of tissues and cell sheets. The driving force for these rearrangements is generated mostly by the actin cytoskeleton. In order to permit the reproducible development of a specific body plan, dynamic reorganization of the actin cytoskeleton must be precisely coordinated in space and time. GTP-exchange factors that activate small GTPases of the Rho family play an important role in this process. Here we review the role of this class of cytoskeletal regulators during important developmental processes such as epithelial morphogenesis, cytokinesis, cell migration, cell polarity, neuronal growth cone extension and phagocytosis in different model systems.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytokinesis, morphogenesis, RhoGEF, myosin, actin, cytoskeleton, GTPase
in
Small GTPases
volume
1
issue
1
pages
28 - 43
publisher
Landes Bioscience
external identifiers
  • pmid:21686118
  • scopus:79952047916
ISSN
2154-1248
DOI
10.4161/sgtp.1.1.12672
language
English
LU publication?
yes
id
c7f935dd-8f1a-4628-8db4-0d4b21bcfb17 (old id 2007927)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21686118?dopt=Abstract
date added to LUP
2011-07-06 10:01:45
date last changed
2018-05-29 12:01:58
@article{c7f935dd-8f1a-4628-8db4-0d4b21bcfb17,
  abstract     = {The development of multicellular organisms is associated with extensive rearrangements of tissues and cell sheets. The driving force for these rearrangements is generated mostly by the actin cytoskeleton. In order to permit the reproducible development of a specific body plan, dynamic reorganization of the actin cytoskeleton must be precisely coordinated in space and time. GTP-exchange factors that activate small GTPases of the Rho family play an important role in this process. Here we review the role of this class of cytoskeletal regulators during important developmental processes such as epithelial morphogenesis, cytokinesis, cell migration, cell polarity, neuronal growth cone extension and phagocytosis in different model systems.},
  author       = {Mulinari, Shai and Häcker, Udo},
  issn         = {2154-1248},
  keyword      = {cytokinesis,morphogenesis,RhoGEF,myosin,actin,cytoskeleton,GTPase},
  language     = {eng},
  number       = {1},
  pages        = {28--43},
  publisher    = {Landes Bioscience},
  series       = {Small GTPases},
  title        = {Rho-guanine nucleotide exchange factors during development: Force is nothing without control.},
  url          = {http://dx.doi.org/10.4161/sgtp.1.1.12672},
  volume       = {1},
  year         = {2010},
}