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Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients.

Wernerman, J; Kirketeig, T; Andersson, B; Berthelson, H; Ersson, Anders LU ; Friberg, Hans LU ; Guttormsen, A B; Hendrikx, S; Pettilä, V and Rossi, P, et al. (2011) In Acta Anaesthesiologica Scandinavica 55. p.812-818
Abstract
Background: Low plasma glutamine concentration is an independent prognostic factor for an unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with glutamine is reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. glutamine supplementation for ICU patients, we investigated outcomes regarding sequential organ failure assessment (SOFA) scores and mortality. The hypothesis was that the change in the SOFA score would be improved by glutamine supplementation. Methods: Patients (n=413) given nutrition by an enteral and/or a parenteral route with the aim of providing full nutrition were included within 72 h after ICU admission. Glutamine was... (More)
Background: Low plasma glutamine concentration is an independent prognostic factor for an unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with glutamine is reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. glutamine supplementation for ICU patients, we investigated outcomes regarding sequential organ failure assessment (SOFA) scores and mortality. The hypothesis was that the change in the SOFA score would be improved by glutamine supplementation. Methods: Patients (n=413) given nutrition by an enteral and/or a parenteral route with the aim of providing full nutrition were included within 72 h after ICU admission. Glutamine was supplemented as i.v. l-alanyl-l-glutamine, 0.283 g glutamine/kg body weight/24 h for the entire ICU stay. Placebo was saline in identical bottles. All included patients were considered as intention-to-treat patients. Patients given supplementation for >3 days were considered as predetermined per protocol (PP) patients. Results: There was a lower ICU mortality in the treatment arm as compared with the controls in the PP group, but not at 6 months. For change in the SOFA scores, no differences were seen, 1 (0,3) vs. 2 (0.4), P=0.792, for the glutamine group and the controls, respectively. Conclusion: In summary, a reduced ICU mortality was observed during i.v. glutamine supplementation in the PP group. The pragmatic design of the study makes the results representative for a broad range of ICU patients. (Less)
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Acta Anaesthesiologica Scandinavica
volume
55
pages
812 - 818
publisher
Wiley-Blackwell
external identifiers
  • wos:000292649500007
  • pmid:21658010
  • scopus:79960343557
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2011.02453.x
language
English
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yes
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447e4edb-f38b-4ba9-a3f2-374f0e450491 (old id 2008286)
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http://www.ncbi.nlm.nih.gov/pubmed/21658010?dopt=Abstract
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2011-07-04 13:39:55
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2017-11-05 04:44:38
@article{447e4edb-f38b-4ba9-a3f2-374f0e450491,
  abstract     = {Background: Low plasma glutamine concentration is an independent prognostic factor for an unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with glutamine is reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. glutamine supplementation for ICU patients, we investigated outcomes regarding sequential organ failure assessment (SOFA) scores and mortality. The hypothesis was that the change in the SOFA score would be improved by glutamine supplementation. Methods: Patients (n=413) given nutrition by an enteral and/or a parenteral route with the aim of providing full nutrition were included within 72 h after ICU admission. Glutamine was supplemented as i.v. l-alanyl-l-glutamine, 0.283 g glutamine/kg body weight/24 h for the entire ICU stay. Placebo was saline in identical bottles. All included patients were considered as intention-to-treat patients. Patients given supplementation for >3 days were considered as predetermined per protocol (PP) patients. Results: There was a lower ICU mortality in the treatment arm as compared with the controls in the PP group, but not at 6 months. For change in the SOFA scores, no differences were seen, 1 (0,3) vs. 2 (0.4), P=0.792, for the glutamine group and the controls, respectively. Conclusion: In summary, a reduced ICU mortality was observed during i.v. glutamine supplementation in the PP group. The pragmatic design of the study makes the results representative for a broad range of ICU patients.},
  author       = {Wernerman, J and Kirketeig, T and Andersson, B and Berthelson, H and Ersson, Anders and Friberg, Hans and Guttormsen, A B and Hendrikx, S and Pettilä, V and Rossi, P and Sjöberg, F and Winsö, O},
  issn         = {0001-5172},
  language     = {eng},
  pages        = {812--818},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients.},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2011.02453.x},
  volume       = {55},
  year         = {2011},
}