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First two decades of paediatric heart transplantation in Sweden - outcome of listing and post-transplant results.

Gilljam, Thomas; Higgins, Thomas; Bennhagen, Rolf LU and Wåhlander, Håkan (2011) In Acta Pædiatrica 100(11). p.1442-1447
Abstract
Aims:  To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods:  Retrospective review of all 135 Swedish children <18 years old listed for heart transplantation 1989-2009, followed to December 31, 2009, including 74 (55%) with cardiomyopathy and 61 (45%) with congenital heart disease; 34 (25%) were infants (<1 year). Cumulative risk of requiring heart transplantation was 1:17 300 (11 patients who improved were omitted from outcome analysis). Results:  Waiting-list mortality was 31% (44% in infants). Median waiting time in 82 transplanted patients was 57 days (0-585 days). Post-transplant follow-up time was median 5.9 years (0.03-20.1 years), and... (More)
Aims:  To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods:  Retrospective review of all 135 Swedish children <18 years old listed for heart transplantation 1989-2009, followed to December 31, 2009, including 74 (55%) with cardiomyopathy and 61 (45%) with congenital heart disease; 34 (25%) were infants (<1 year). Cumulative risk of requiring heart transplantation was 1:17 300 (11 patients who improved were omitted from outcome analysis). Results:  Waiting-list mortality was 31% (44% in infants). Median waiting time in 82 transplanted patients was 57 days (0-585 days). Post-transplant follow-up time was median 5.9 years (0.03-20.1 years), and actuarial survival was 92% at 1 year, 82% at 5 years, 76% at 10 years and 58% at 15 years. Survival after listing was 64% at 1 year, 58% at 5 years, 52% at 10 years and 40% at 15 years. Post-transplant complications included rejections (34%), malignancies (12%), renal failure (8%), coronary artery vasculopathy (6%) and re-transplantation (5%). Among 64 survivors, 84% were free of complications affecting prognosis. Conclusion:  High waiting-list mortality and post-transplant attrition precluded 60% of this pioneer population from reaching adulthood. Functional status in survivors is generally good. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Complications, Heart transplantation, Paediatric cardiology, Survival
in
Acta Pædiatrica
volume
100
issue
11
pages
1442 - 1447
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000296421300019
  • pmid:21645110
  • scopus:80054019469
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2011.02377.x
language
English
LU publication?
yes
id
1d681a1b-15e7-456a-9fdf-f6deaabe7772 (old id 2008437)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21645110?dopt=Abstract
date added to LUP
2012-01-18 16:07:33
date last changed
2017-11-12 03:14:24
@article{1d681a1b-15e7-456a-9fdf-f6deaabe7772,
  abstract     = {Aims:  To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods:  Retrospective review of all 135 Swedish children &lt;18 years old listed for heart transplantation 1989-2009, followed to December 31, 2009, including 74 (55%) with cardiomyopathy and 61 (45%) with congenital heart disease; 34 (25%) were infants (&lt;1 year). Cumulative risk of requiring heart transplantation was 1:17 300 (11 patients who improved were omitted from outcome analysis). Results:  Waiting-list mortality was 31% (44% in infants). Median waiting time in 82 transplanted patients was 57 days (0-585 days). Post-transplant follow-up time was median 5.9 years (0.03-20.1 years), and actuarial survival was 92% at 1 year, 82% at 5 years, 76% at 10 years and 58% at 15 years. Survival after listing was 64% at 1 year, 58% at 5 years, 52% at 10 years and 40% at 15 years. Post-transplant complications included rejections (34%), malignancies (12%), renal failure (8%), coronary artery vasculopathy (6%) and re-transplantation (5%). Among 64 survivors, 84% were free of complications affecting prognosis. Conclusion:  High waiting-list mortality and post-transplant attrition precluded 60% of this pioneer population from reaching adulthood. Functional status in survivors is generally good.},
  author       = {Gilljam, Thomas and Higgins, Thomas and Bennhagen, Rolf and Wåhlander, Håkan},
  issn         = {1651-2227},
  keyword      = {Complications,Heart transplantation,Paediatric cardiology,Survival},
  language     = {eng},
  number       = {11},
  pages        = {1442--1447},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {First two decades of paediatric heart transplantation in Sweden - outcome of listing and post-transplant results.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2011.02377.x},
  volume       = {100},
  year         = {2011},
}