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From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population.

Fava, Cristiano LU ; Montagnana, Martina LU ; Guidi, Gian Cesare and Melander, Olle LU (2012) In Annals of Medicine 44(5). p.433-447
Abstract
Abstract Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few but consistent loci or genes which are independently associated with CV risk. The idea is fascinating that these genetic markers could lead to improved individual CV risk assessment and tailored pharmacological interventions. In this brief review we will not make a systematic review of all non-genetic and genetic markers of CV risk but we will try... (More)
Abstract Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few but consistent loci or genes which are independently associated with CV risk. The idea is fascinating that these genetic markers could lead to improved individual CV risk assessment and tailored pharmacological interventions. In this brief review we will not make a systematic review of all non-genetic and genetic markers of CV risk but we will try to make a brief overview of the most interesting ones with the aim to underline potential 'pros' and 'cons' of their implementation in clinical practice. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Medicine
volume
44
issue
5
pages
433 - 447
publisher
Informa Healthcare
external identifiers
  • wos:000306523700003
  • pmid:21623699
  • scopus:84864033399
ISSN
1365-2060
DOI
10.3109/07853890.2011.582511
language
English
LU publication?
yes
id
c18e04a3-7721-4a87-a694-19ba271139be (old id 2008734)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21623699?dopt=Abstract
date added to LUP
2011-07-01 11:34:24
date last changed
2017-01-01 03:58:26
@article{c18e04a3-7721-4a87-a694-19ba271139be,
  abstract     = {Abstract Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few but consistent loci or genes which are independently associated with CV risk. The idea is fascinating that these genetic markers could lead to improved individual CV risk assessment and tailored pharmacological interventions. In this brief review we will not make a systematic review of all non-genetic and genetic markers of CV risk but we will try to make a brief overview of the most interesting ones with the aim to underline potential 'pros' and 'cons' of their implementation in clinical practice.},
  author       = {Fava, Cristiano and Montagnana, Martina and Guidi, Gian Cesare and Melander, Olle},
  issn         = {1365-2060},
  language     = {eng},
  number       = {5},
  pages        = {433--447},
  publisher    = {Informa Healthcare},
  series       = {Annals of Medicine},
  title        = {From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population.},
  url          = {http://dx.doi.org/10.3109/07853890.2011.582511},
  volume       = {44},
  year         = {2012},
}