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Protein C Inhibitor

Meijers, Joost C. M. and Herwald, Heiko LU orcid (2011) In Seminars in Thrombosis and Hemostasis 37(4). p.349-354
Abstract
Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility. The biological function of PCI is unknown due to broad enzyme specificity, its wide tissue distribution, and the lack of a suitable animal model. This review highlights the specific roles of PCI in the areas of hemostasis and thrombosis and fertilization, and it also describes the latest information on the fascinating participation of the protein in intracellular processes, phospholipid binding, and killing of bacteria.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Protein C inhibitor, SERPIN, inhibition
in
Seminars in Thrombosis and Hemostasis
volume
37
issue
4
pages
349 - 354
publisher
Georg Thieme Verlag KG
external identifiers
  • wos:000292278800003
  • scopus:79961061714
  • pmid:21805440
ISSN
1098-9064
DOI
10.1055/s-0031-1276583
language
English
LU publication?
yes
id
f74b74ac-0a38-4663-8933-5b6ffa57da99 (old id 2029166)
date added to LUP
2016-04-01 14:10:42
date last changed
2020-01-15 04:41:53
@article{f74b74ac-0a38-4663-8933-5b6ffa57da99,
  abstract     = {Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility. The biological function of PCI is unknown due to broad enzyme specificity, its wide tissue distribution, and the lack of a suitable animal model. This review highlights the specific roles of PCI in the areas of hemostasis and thrombosis and fertilization, and it also describes the latest information on the fascinating participation of the protein in intracellular processes, phospholipid binding, and killing of bacteria.},
  author       = {Meijers, Joost C. M. and Herwald, Heiko},
  issn         = {1098-9064},
  language     = {eng},
  number       = {4},
  pages        = {349--354},
  publisher    = {Georg Thieme Verlag KG},
  series       = {Seminars in Thrombosis and Hemostasis},
  title        = {Protein C Inhibitor},
  url          = {http://dx.doi.org/10.1055/s-0031-1276583},
  doi          = {10.1055/s-0031-1276583},
  volume       = {37},
  year         = {2011},
}