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Hyperpnea-Induced Bronchoconstriction and Urinary CC16 Levels in Athletes

Bolger, Claire; Tufvesson, Ellen LU ; Sue-Chu, Malcolm; Devereux, Graham; Ayres, Jon G.; Bjermer, Leif LU and Kippelen, Pascale (2011) In Medicine & Science in Sports & Exercise 43(7). p.1207-1213
Abstract
BOLGER, C., E. TUFVESSON, M. SUE-CHU, G. DEVEREUX, J. G. AYRES, L. BJERMER, and P. KIPPELEN. Hyperpnea-Induced Bronchoconstriction and Urinary CC16 Levels in Athletes. Med. Sci. Sports Exerc., Vol. 43, No. 7, pp. 1207-1213, 2011. Purpose: Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes. Although excessive water loss by peripheral airways during hyperpnea is regarded as the initial trigger for EIB, the cascade of events that follows remains unclear. Our goal was to establish whether transient disruption of the airway epithelial barrier occurs after a short period of hyperpnea of dry air in athletes with EIB. Methods: Urinary concentration of the... (More)
BOLGER, C., E. TUFVESSON, M. SUE-CHU, G. DEVEREUX, J. G. AYRES, L. BJERMER, and P. KIPPELEN. Hyperpnea-Induced Bronchoconstriction and Urinary CC16 Levels in Athletes. Med. Sci. Sports Exerc., Vol. 43, No. 7, pp. 1207-1213, 2011. Purpose: Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes. Although excessive water loss by peripheral airways during hyperpnea is regarded as the initial trigger for EIB, the cascade of events that follows remains unclear. Our goal was to establish whether transient disruption of the airway epithelial barrier occurs after a short period of hyperpnea of dry air in athletes with EIB. Methods: Urinary concentration of the pneumoprotein Clara cell (CC16) was used as an assumed biomarker of lung epithelial cell damage or dysfunction. Samples were collected at baseline and for 90 min after an 8-min eucapnic voluntary hyperpnea (EVH) test in 50 female individuals (28 athletes and 22 untrained). Results: Nineteen subjects (10 athletes) demonstrated a sustained bronchoconstriction after EVH (mean +/- SE forced expiratory volume in the first second (FEV1) fall from baseline = 23.4% +/- 2.6%). The remaining subjects had a negative challenge result with an FEV1 fall of 5.9% +/- 0.6%. An increase (P < 0.001) in urinary CC16 concentration was noticed after EVH in all but one subject, with no group difference (median CC16 increase before to after challenge: athletes EVH- 0.083 ng.mu mol(-1), athletes EVH+ 0.223 ng.mu mol(-1), untrained EVH- 0.074 ng.mu mol(-1), untrained EVH+ 0.571 ng.mu mol(-1); P > 0.05). Conclusions: Urinary levels of CC16 are increased after EVH in all individuals (trained and untrained, with and without EIB) suggestive of dehydration-induced perturbation of the distal respiratory epithelium during episodes of hyperventilation. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
EXERCISE-INDUCED BRONCHOCONSTRICTION, ASTHMA, EPITHELIAL INJURY, EUCAPNIC VOLUNTARY HYPERPNEA, FEMALES
in
Medicine & Science in Sports & Exercise
volume
43
issue
7
pages
1207 - 1213
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000291924500010
  • scopus:79959860128
  • pmid:21131866
ISSN
1530-0315
DOI
10.1249/MSS.0b013e31820750d8
language
English
LU publication?
yes
id
ff114ccd-fb07-4f3c-acad-e4971dd423f7 (old id 2042227)
date added to LUP
2011-08-02 08:58:59
date last changed
2017-05-28 03:27:06
@article{ff114ccd-fb07-4f3c-acad-e4971dd423f7,
  abstract     = {BOLGER, C., E. TUFVESSON, M. SUE-CHU, G. DEVEREUX, J. G. AYRES, L. BJERMER, and P. KIPPELEN. Hyperpnea-Induced Bronchoconstriction and Urinary CC16 Levels in Athletes. Med. Sci. Sports Exerc., Vol. 43, No. 7, pp. 1207-1213, 2011. Purpose: Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes. Although excessive water loss by peripheral airways during hyperpnea is regarded as the initial trigger for EIB, the cascade of events that follows remains unclear. Our goal was to establish whether transient disruption of the airway epithelial barrier occurs after a short period of hyperpnea of dry air in athletes with EIB. Methods: Urinary concentration of the pneumoprotein Clara cell (CC16) was used as an assumed biomarker of lung epithelial cell damage or dysfunction. Samples were collected at baseline and for 90 min after an 8-min eucapnic voluntary hyperpnea (EVH) test in 50 female individuals (28 athletes and 22 untrained). Results: Nineteen subjects (10 athletes) demonstrated a sustained bronchoconstriction after EVH (mean +/- SE forced expiratory volume in the first second (FEV1) fall from baseline = 23.4% +/- 2.6%). The remaining subjects had a negative challenge result with an FEV1 fall of 5.9% +/- 0.6%. An increase (P &lt; 0.001) in urinary CC16 concentration was noticed after EVH in all but one subject, with no group difference (median CC16 increase before to after challenge: athletes EVH- 0.083 ng.mu mol(-1), athletes EVH+ 0.223 ng.mu mol(-1), untrained EVH- 0.074 ng.mu mol(-1), untrained EVH+ 0.571 ng.mu mol(-1); P &gt; 0.05). Conclusions: Urinary levels of CC16 are increased after EVH in all individuals (trained and untrained, with and without EIB) suggestive of dehydration-induced perturbation of the distal respiratory epithelium during episodes of hyperventilation.},
  author       = {Bolger, Claire and Tufvesson, Ellen and Sue-Chu, Malcolm and Devereux, Graham and Ayres, Jon G. and Bjermer, Leif and Kippelen, Pascale},
  issn         = {1530-0315},
  keyword      = {EXERCISE-INDUCED BRONCHOCONSTRICTION,ASTHMA,EPITHELIAL INJURY,EUCAPNIC VOLUNTARY HYPERPNEA,FEMALES},
  language     = {eng},
  number       = {7},
  pages        = {1207--1213},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Medicine & Science in Sports & Exercise},
  title        = {Hyperpnea-Induced Bronchoconstriction and Urinary CC16 Levels in Athletes},
  url          = {http://dx.doi.org/10.1249/MSS.0b013e31820750d8},
  volume       = {43},
  year         = {2011},
}