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Platelets and innate immunity

Semple, John W LU and Freedman, John (2010) In Cellular and Molecular Life Sciences 67(4). p.499-511
Abstract

Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active role in both innate and adaptive immunity. For example, platelet adhesive interactions with leukocytes and endothelial cells via P-selectin can lead to several pro-inflammatory events, including leukocyte rolling and activation, production of cytokine cascades, and recruitment of the leukocytes to sites of tissue damage. Superimposed on this, platelets express immunologically-related molecules such as CD40L and Toll-like receptors that have been shown to functionally modulate innate immunity. Furthermore, platelets themselves can... (More)

Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active role in both innate and adaptive immunity. For example, platelet adhesive interactions with leukocytes and endothelial cells via P-selectin can lead to several pro-inflammatory events, including leukocyte rolling and activation, production of cytokine cascades, and recruitment of the leukocytes to sites of tissue damage. Superimposed on this, platelets express immunologically-related molecules such as CD40L and Toll-like receptors that have been shown to functionally modulate innate immunity. Furthermore, platelets themselves can interact with microorganisms, and several viruses have been shown to cross-react immunologically with platelet antigens. This review discusses the central role that platelets play in inflammation, linking them with varied pathological conditions, such as atherosclerosis, sepsis, and immune thrombocytopenic purpura, and suggests that platelets also act as primary mediators of our innate defences.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Acute Lung Injury, Adaptive Immunity, Atherosclerosis, Blood Platelets, Humans, Immunity, Innate, Inflammation, Membrane Glycoproteins, Neutrophils, Platelet Transfusion, Receptors, Immunologic, Sepsis, Toll-Like Receptors, Journal Article, Review
in
Cellular and Molecular Life Sciences
volume
67
issue
4
pages
499 - 511
publisher
Birkhaüser
external identifiers
  • scopus:75649130466
ISSN
1420-9071
DOI
10.1007/s00018-009-0205-1
language
English
LU publication?
no
id
20520592-79fd-4f7b-84b1-5351ef9a6c3d
date added to LUP
2016-09-23 12:07:20
date last changed
2017-04-23 04:53:28
@article{20520592-79fd-4f7b-84b1-5351ef9a6c3d,
  abstract     = {<p>Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active role in both innate and adaptive immunity. For example, platelet adhesive interactions with leukocytes and endothelial cells via P-selectin can lead to several pro-inflammatory events, including leukocyte rolling and activation, production of cytokine cascades, and recruitment of the leukocytes to sites of tissue damage. Superimposed on this, platelets express immunologically-related molecules such as CD40L and Toll-like receptors that have been shown to functionally modulate innate immunity. Furthermore, platelets themselves can interact with microorganisms, and several viruses have been shown to cross-react immunologically with platelet antigens. This review discusses the central role that platelets play in inflammation, linking them with varied pathological conditions, such as atherosclerosis, sepsis, and immune thrombocytopenic purpura, and suggests that platelets also act as primary mediators of our innate defences.</p>},
  author       = {Semple, John W and Freedman, John},
  issn         = {1420-9071},
  keyword      = {Acute Lung Injury,Adaptive Immunity,Atherosclerosis,Blood Platelets,Humans,Immunity, Innate,Inflammation,Membrane Glycoproteins,Neutrophils,Platelet Transfusion,Receptors, Immunologic,Sepsis,Toll-Like Receptors,Journal Article,Review},
  language     = {eng},
  number       = {4},
  pages        = {499--511},
  publisher    = {Birkhaüser},
  series       = {Cellular and Molecular Life Sciences},
  title        = {Platelets and innate immunity},
  url          = {http://dx.doi.org/10.1007/s00018-009-0205-1},
  volume       = {67},
  year         = {2010},
}