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Genetics of innate immunity and UTI susceptibility.

Ragnarsdottir, Bryndis LU ; Lutay, Nataliya LU ; Grönberg Hernandez, Jenny LU ; Köves, Béla LU and Svanborg, Catharina LU (2011) In Nature Reviews Urology 8. p.449-468
Abstract
A functional and well-balanced immune response is required to resist most infections. Slight dysfunctions in innate immunity can turn the 'friendly' host defense into an unpleasant foe and give rise to disease. Beneficial and destructive forces of innate immunity have been discovered in the urinary tract and mechanisms by which they influence the severity of urinary tract infections (UTIs) have been elucidated. By modifying specific aspects of the innate immune response to UTI, genetic variation either exaggerates the severity of acute pyelonephritis to include urosepsis and renal scarring or protects against symptomatic disease by suppressing innate immune signaling, as in asymptomatic bacteriuria (ABU). Different genes are polymorphic in... (More)
A functional and well-balanced immune response is required to resist most infections. Slight dysfunctions in innate immunity can turn the 'friendly' host defense into an unpleasant foe and give rise to disease. Beneficial and destructive forces of innate immunity have been discovered in the urinary tract and mechanisms by which they influence the severity of urinary tract infections (UTIs) have been elucidated. By modifying specific aspects of the innate immune response to UTI, genetic variation either exaggerates the severity of acute pyelonephritis to include urosepsis and renal scarring or protects against symptomatic disease by suppressing innate immune signaling, as in asymptomatic bacteriuria (ABU). Different genes are polymorphic in patients prone to acute pyelonephritis or ABU, respectively, and yet discussions of UTI susceptibility in clinical practice still focus mainly on social and behavioral factors or dysfunctional voiding. Is it not time for UTIs to enter the era of molecular medicine? Defining why certain individuals are protected from UTI while others have severe, recurrent infections has long been difficult, but progress is now being made, encouraging new approaches to risk assessment and therapy in this large and important patient group, as well as revealing promising facets of 'good' versus 'bad' inflammation. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Nature Reviews Urology
volume
8
pages
449 - 468
publisher
Nature Publishing Group
external identifiers
  • wos:000293786200006
  • pmid:21750501
  • scopus:80051679794
ISSN
1759-4820
DOI
10.1038/nrurol.2011.100
language
English
LU publication?
yes
id
6c81f993-1896-4ed2-a6b2-ffc2836371a9 (old id 2058690)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21750501?dopt=Abstract
date added to LUP
2011-08-01 13:17:53
date last changed
2017-06-25 04:34:25
@article{6c81f993-1896-4ed2-a6b2-ffc2836371a9,
  abstract     = {A functional and well-balanced immune response is required to resist most infections. Slight dysfunctions in innate immunity can turn the 'friendly' host defense into an unpleasant foe and give rise to disease. Beneficial and destructive forces of innate immunity have been discovered in the urinary tract and mechanisms by which they influence the severity of urinary tract infections (UTIs) have been elucidated. By modifying specific aspects of the innate immune response to UTI, genetic variation either exaggerates the severity of acute pyelonephritis to include urosepsis and renal scarring or protects against symptomatic disease by suppressing innate immune signaling, as in asymptomatic bacteriuria (ABU). Different genes are polymorphic in patients prone to acute pyelonephritis or ABU, respectively, and yet discussions of UTI susceptibility in clinical practice still focus mainly on social and behavioral factors or dysfunctional voiding. Is it not time for UTIs to enter the era of molecular medicine? Defining why certain individuals are protected from UTI while others have severe, recurrent infections has long been difficult, but progress is now being made, encouraging new approaches to risk assessment and therapy in this large and important patient group, as well as revealing promising facets of 'good' versus 'bad' inflammation.},
  author       = {Ragnarsdottir, Bryndis and Lutay, Nataliya and Grönberg Hernandez, Jenny and Köves, Béla and Svanborg, Catharina},
  issn         = {1759-4820},
  language     = {eng},
  pages        = {449--468},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Urology},
  title        = {Genetics of innate immunity and UTI susceptibility.},
  url          = {http://dx.doi.org/10.1038/nrurol.2011.100},
  volume       = {8},
  year         = {2011},
}