Advanced

Quantitative disease resistance: to better understand parasite-mediated selection on major histocompatibility complex.

Westerdahl, Helena LU ; Muhammad, Asghar LU ; Hasselquist, Dennis LU and Bensch, Staffan LU (2012) In Proceedings of the Royal Society B: Biological Sciences 279. p.577-584
Abstract
We outline a descriptive framework of how candidate alleles of the immune system associate with infectious diseases in natural populations of animals. Three kinds of alleles can be separated when both prevalence of infection and infection intensity are measured-qualitative disease resistance, quantitative disease resistance and susceptibility alleles. Our descriptive framework demonstrates why alleles for quantitative resistance and susceptibility cannot be separated based on prevalence data alone, but are distinguishable on infection intensity. We then present a case study to evaluate a previous finding of a positive association between prevalence of a severe avian malaria infection (GRW2, Plasmodium ashfordi) and a major... (More)
We outline a descriptive framework of how candidate alleles of the immune system associate with infectious diseases in natural populations of animals. Three kinds of alleles can be separated when both prevalence of infection and infection intensity are measured-qualitative disease resistance, quantitative disease resistance and susceptibility alleles. Our descriptive framework demonstrates why alleles for quantitative resistance and susceptibility cannot be separated based on prevalence data alone, but are distinguishable on infection intensity. We then present a case study to evaluate a previous finding of a positive association between prevalence of a severe avian malaria infection (GRW2, Plasmodium ashfordi) and a major histocompatibility complex (MHC) class I allele (B4b) in great reed warblers Acrocephalus arundinaceus. Using the same dataset, we find that individuals with allele B4b have lower GRW2 infection intensities than individuals without this allele. Therefore, allele B4b provides quantitative resistance rather than increasing susceptibility to infection. This implies that birds carrying B4b can mount an immune response that suppresses the acute-phase GRW2 infection, while birds without this allele cannot and may die. We argue that it is important to determine whether MHC alleles related to infections are advantageous (quantitative and qualitative resistance) or disadvantageous (susceptibility) to obtain a more complete picture of pathogen-mediated balancing selection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Proceedings of the Royal Society B: Biological Sciences
volume
279
pages
577 - 584
publisher
Royal Society
external identifiers
  • wos:000298661700021
  • pmid:21733902
  • scopus:84055222357
ISSN
1471-2954
DOI
10.1098/rspb.2011.0917
project
Avian MHC genes
CAnMove
language
English
LU publication?
yes
id
9d50f3f8-68f6-41ad-b040-6a2770403322 (old id 2058912)
date added to LUP
2011-07-27 09:32:04
date last changed
2017-10-08 03:59:30
@article{9d50f3f8-68f6-41ad-b040-6a2770403322,
  abstract     = {We outline a descriptive framework of how candidate alleles of the immune system associate with infectious diseases in natural populations of animals. Three kinds of alleles can be separated when both prevalence of infection and infection intensity are measured-qualitative disease resistance, quantitative disease resistance and susceptibility alleles. Our descriptive framework demonstrates why alleles for quantitative resistance and susceptibility cannot be separated based on prevalence data alone, but are distinguishable on infection intensity. We then present a case study to evaluate a previous finding of a positive association between prevalence of a severe avian malaria infection (GRW2, Plasmodium ashfordi) and a major histocompatibility complex (MHC) class I allele (B4b) in great reed warblers Acrocephalus arundinaceus. Using the same dataset, we find that individuals with allele B4b have lower GRW2 infection intensities than individuals without this allele. Therefore, allele B4b provides quantitative resistance rather than increasing susceptibility to infection. This implies that birds carrying B4b can mount an immune response that suppresses the acute-phase GRW2 infection, while birds without this allele cannot and may die. We argue that it is important to determine whether MHC alleles related to infections are advantageous (quantitative and qualitative resistance) or disadvantageous (susceptibility) to obtain a more complete picture of pathogen-mediated balancing selection.},
  author       = {Westerdahl, Helena and Muhammad, Asghar and Hasselquist, Dennis and Bensch, Staffan},
  issn         = {1471-2954},
  language     = {eng},
  pages        = {577--584},
  publisher    = {Royal Society},
  series       = {Proceedings of the Royal Society B: Biological Sciences},
  title        = {Quantitative disease resistance: to better understand parasite-mediated selection on major histocompatibility complex.},
  url          = {http://dx.doi.org/10.1098/rspb.2011.0917},
  volume       = {279},
  year         = {2012},
}