Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro.
(2011) In Reproductive Toxicology 32(3). p.293-297- Abstract
- Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat... (More)
- Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058950
- author
- Björk, Christel LU ; Nenonen, Hannah LU ; Giwercman, Aleksander LU ; Bergman, Ake ; Rylander, Lars LU and Giwercman, Yvonne LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive Toxicology
- volume
- 32
- issue
- 3
- pages
- 293 - 297
- publisher
- Elsevier
- external identifiers
-
- wos:000296935100006
- pmid:21729750
- scopus:80755133521
- pmid:21729750
- ISSN
- 1873-1708
- DOI
- 10.1016/j.reprotox.2011.06.075
- language
- English
- LU publication?
- yes
- id
- bfc1d7cf-6e15-478d-a87e-03a8d0736e5a (old id 2058950)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21729750?dopt=Abstract
- date added to LUP
- 2016-04-01 13:41:22
- date last changed
- 2022-01-27 20:31:45
@article{bfc1d7cf-6e15-478d-a87e-03a8d0736e5a, abstract = {{Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity.}}, author = {{Björk, Christel and Nenonen, Hannah and Giwercman, Aleksander and Bergman, Ake and Rylander, Lars and Giwercman, Yvonne}}, issn = {{1873-1708}}, language = {{eng}}, number = {{3}}, pages = {{293--297}}, publisher = {{Elsevier}}, series = {{Reproductive Toxicology}}, title = {{Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro.}}, url = {{https://lup.lub.lu.se/search/files/3533208/2223565.pdf}}, doi = {{10.1016/j.reprotox.2011.06.075}}, volume = {{32}}, year = {{2011}}, }