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Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro.

Björk, Christel LU ; Nenonen, Hannah LU ; Giwercman, Aleksander LU ; Bergman, Ake; Rylander, Lars LU and Giwercman, Yvonne LU (2011) In Reproductive Toxicology 32(3). p.293-297
Abstract
Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat... (More)
Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Reproductive Toxicology
volume
32
issue
3
pages
293 - 297
publisher
Elsevier
external identifiers
  • wos:000296935100006
  • pmid:21729750
  • scopus:80755133521
ISSN
1873-1708
DOI
10.1016/j.reprotox.2011.06.075
language
English
LU publication?
yes
id
bfc1d7cf-6e15-478d-a87e-03a8d0736e5a (old id 2058950)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21729750?dopt=Abstract
date added to LUP
2011-08-01 18:58:04
date last changed
2017-01-08 04:29:08
@article{bfc1d7cf-6e15-478d-a87e-03a8d0736e5a,
  abstract     = {Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity.},
  author       = {Björk, Christel and Nenonen, Hannah and Giwercman, Aleksander and Bergman, Ake and Rylander, Lars and Giwercman, Yvonne},
  issn         = {1873-1708},
  language     = {eng},
  number       = {3},
  pages        = {293--297},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro.},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2011.06.075},
  volume       = {32},
  year         = {2011},
}