Population based study of prognostic factors and treatment in adult Burkitt lymphoma: a Swedish Lymphoma Registry study.
(2011) In Leukemia & Lymphoma 52(11). p.2090-2096- Abstract
- Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival... (More)
- Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival of 91.2%, 58.4%, and 27.5%, respectively. High-intensity regimens were associated with more favorable overall survival. Rituximab addition was not significantly associated with improvement in survival. A modified prognostic index may be valuable for adult BL, as proposed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2059228
- author
- Wästerlid, Tove LU ; Jonsson, Björn ; Hagberg, Hans and Jerkeman, Mats LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Leukemia & Lymphoma
- volume
- 52
- issue
- 11
- pages
- 2090 - 2096
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000296163000012
- pmid:21718134
- scopus:80055024053
- pmid:21718134
- ISSN
- 1029-2403
- DOI
- 10.3109/10428194.2011.593274
- language
- English
- LU publication?
- yes
- id
- a837299d-d125-4948-b435-ff24aac82889 (old id 2059228)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21718134?dopt=Abstract
- date added to LUP
- 2016-04-01 14:08:14
- date last changed
- 2022-04-14 08:09:17
@article{a837299d-d125-4948-b435-ff24aac82889,
abstract = {{Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival of 91.2%, 58.4%, and 27.5%, respectively. High-intensity regimens were associated with more favorable overall survival. Rituximab addition was not significantly associated with improvement in survival. A modified prognostic index may be valuable for adult BL, as proposed.}},
author = {{Wästerlid, Tove and Jonsson, Björn and Hagberg, Hans and Jerkeman, Mats}},
issn = {{1029-2403}},
language = {{eng}},
number = {{11}},
pages = {{2090--2096}},
publisher = {{Taylor & Francis}},
series = {{Leukemia & Lymphoma}},
title = {{Population based study of prognostic factors and treatment in adult Burkitt lymphoma: a Swedish Lymphoma Registry study.}},
url = {{https://lup.lub.lu.se/search/files/3810493/2222285.pdf}},
doi = {{10.3109/10428194.2011.593274}},
volume = {{52}},
year = {{2011}},
}