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Population based study of prognostic factors and treatment in adult Burkitt lymphoma: a Swedish Lymphoma Registry study.

Wästerlid, Tove LU ; Jonsson, Björn; Hagberg, Hans and Jerkeman, Mats LU (2011) In Leukemia & lymphoma 52(11). p.2090-2096
Abstract
Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival... (More)
Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival of 91.2%, 58.4%, and 27.5%, respectively. High-intensity regimens were associated with more favorable overall survival. Rituximab addition was not significantly associated with improvement in survival. A modified prognostic index may be valuable for adult BL, as proposed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia & lymphoma
volume
52
issue
11
pages
2090 - 2096
publisher
Taylor & Francis
external identifiers
  • wos:000296163000012
  • pmid:21718134
  • scopus:80055024053
ISSN
1029-2403
DOI
10.3109/10428194.2011.593274
language
English
LU publication?
yes
id
a837299d-d125-4948-b435-ff24aac82889 (old id 2059228)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21718134?dopt=Abstract
date added to LUP
2011-08-01 18:52:13
date last changed
2017-10-22 04:15:57
@article{a837299d-d125-4948-b435-ff24aac82889,
  abstract     = {Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival of 91.2%, 58.4%, and 27.5%, respectively. High-intensity regimens were associated with more favorable overall survival. Rituximab addition was not significantly associated with improvement in survival. A modified prognostic index may be valuable for adult BL, as proposed.},
  author       = {Wästerlid, Tove and Jonsson, Björn and Hagberg, Hans and Jerkeman, Mats},
  issn         = {1029-2403},
  language     = {eng},
  number       = {11},
  pages        = {2090--2096},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & lymphoma},
  title        = {Population based study of prognostic factors and treatment in adult Burkitt lymphoma: a Swedish Lymphoma Registry study.},
  url          = {http://dx.doi.org/10.3109/10428194.2011.593274},
  volume       = {52},
  year         = {2011},
}