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Endovascular Coiling of the Ophthalmic Artery in Pigs to Induce Retinal Ischemia

Morén, Håkan LU ; Gesslein, Bodil LU ; Undren, Per; Andréasson, Sten LU and Malmsjö, Malin LU (2011) In Investigative Ophthalmology & Visual Science 52(7). p.4880-4885
Abstract
PURPOSE. The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was investigated. METHODS. The ophthalmic artery was catheterized through the external carotid system using a fluoroscopy-monitored, transfemoral, endovascular approach in 12 pigs (mean weight, 70 kg). The effects were evaluated using angiography and multifocal electroretinography. RESULTS. Occlusion of arteries supplying the retina was established... (More)
PURPOSE. The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was investigated. METHODS. The ophthalmic artery was catheterized through the external carotid system using a fluoroscopy-monitored, transfemoral, endovascular approach in 12 pigs (mean weight, 70 kg). The effects were evaluated using angiography and multifocal electroretinography. RESULTS. Occlusion of arteries supplying the retina was established using endovascular coiling. Coiling in the proximal part of the ophthalmic artery caused no or little ischemia, presumably because of collateral blood supply. Coiling in the distal part of the ophthalmic artery, over the branching of the main ciliary artery, caused more severe retinal ischemia. Multifocal electroretinography recordings, which reflect retinal function in an area close to the visual streak, showed decreased amplitudes and increased implicit times after distal occlusion, but not after proximal occlusion of the ophthalmic artery. The responses were similar 1 hour and 72 hours after coiling, indicating that a permanent ischemic injury was established. CONCLUSIONS. The porcine ophthalmic artery can be occluded using an endovascular coiling technique. This provides an experimental animal model of retinal ischemia in which occlusion at different sites of the vasculature produces different degrees of severity of the ischemic damage. (Invest Ophthalmol Vis Sci. 2011;52:4880-4885) DOI:10.1167/iovs.11-7628 (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Investigative Ophthalmology & Visual Science
volume
52
issue
7
pages
4880 - 4885
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • wos:000293332500127
  • scopus:80052367203
ISSN
1552-5783
DOI
10.1167/iovs.11-7628
language
English
LU publication?
yes
id
069b24c1-8e40-44f5-9ffe-4ba19cd1cf5f (old id 2065452)
date added to LUP
2011-09-02 08:27:46
date last changed
2017-01-01 06:12:30
@article{069b24c1-8e40-44f5-9ffe-4ba19cd1cf5f,
  abstract     = {PURPOSE. The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was investigated. METHODS. The ophthalmic artery was catheterized through the external carotid system using a fluoroscopy-monitored, transfemoral, endovascular approach in 12 pigs (mean weight, 70 kg). The effects were evaluated using angiography and multifocal electroretinography. RESULTS. Occlusion of arteries supplying the retina was established using endovascular coiling. Coiling in the proximal part of the ophthalmic artery caused no or little ischemia, presumably because of collateral blood supply. Coiling in the distal part of the ophthalmic artery, over the branching of the main ciliary artery, caused more severe retinal ischemia. Multifocal electroretinography recordings, which reflect retinal function in an area close to the visual streak, showed decreased amplitudes and increased implicit times after distal occlusion, but not after proximal occlusion of the ophthalmic artery. The responses were similar 1 hour and 72 hours after coiling, indicating that a permanent ischemic injury was established. CONCLUSIONS. The porcine ophthalmic artery can be occluded using an endovascular coiling technique. This provides an experimental animal model of retinal ischemia in which occlusion at different sites of the vasculature produces different degrees of severity of the ischemic damage. (Invest Ophthalmol Vis Sci. 2011;52:4880-4885) DOI:10.1167/iovs.11-7628},
  author       = {Morén, Håkan and Gesslein, Bodil and Undren, Per and Andréasson, Sten and Malmsjö, Malin},
  issn         = {1552-5783},
  language     = {eng},
  number       = {7},
  pages        = {4880--4885},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology & Visual Science},
  title        = {Endovascular Coiling of the Ophthalmic Artery in Pigs to Induce Retinal Ischemia},
  url          = {http://dx.doi.org/10.1167/iovs.11-7628},
  volume       = {52},
  year         = {2011},
}