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HPLC-EAT (Environmental Assessment Tool): A tool for profiling safety, health and environmental impacts of liquid chromatography methods

Gaber, Yasser LU ; Törnvall, Ulrika LU ; Kumar, M A LU ; Amin, Magdy Ali and Hatti-Kaul, Rajni LU (2011) In Green Chemistry 13(8). p.2021-2025
Abstract
A simple and efficient approach for profiling the greenness of high performance liquid chromatography (HPLC) methods is presented. This environmental assessment tool (EAT) takes into consideration the environmental, health and safety issues for all solvents involved in the chromatographic method, and calculates a total score that can be used for comparison of the greenness of different methods. A software, HPLC-EAT, has been designed to facilitate the calculation and can be downloaded free of charge at http://www.biotek.lu.se/hplc-eat/. HPLC-EAT was successfully applied for a set of different HPLC methods from the literature, including both analytical and preparative chromatography. The performance of the tool was validated and it was... (More)
A simple and efficient approach for profiling the greenness of high performance liquid chromatography (HPLC) methods is presented. This environmental assessment tool (EAT) takes into consideration the environmental, health and safety issues for all solvents involved in the chromatographic method, and calculates a total score that can be used for comparison of the greenness of different methods. A software, HPLC-EAT, has been designed to facilitate the calculation and can be downloaded free of charge at http://www.biotek.lu.se/hplc-eat/. HPLC-EAT was successfully applied for a set of different HPLC methods from the literature, including both analytical and preparative chromatography. The performance of the tool was validated and it was further combined with another free software Eco-solvent tool to perform life cycle assessments of waste disposal options of distillation or incineration. HPLC-EAT can be routinely used in method development to calculate the greenness beside the conventional standards of accuracy, robustness and reproducibility. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Green Chemistry
volume
13
issue
8
pages
2021 - 2025
publisher
Royal Society of Chemistry
external identifiers
  • wos:000293518300014
  • scopus:80051591884
ISSN
1463-9270
DOI
10.1039/c0gc00667j
language
English
LU publication?
yes
id
80ed9036-cece-4dcf-beb9-2464142977f1 (old id 2065469)
date added to LUP
2011-08-29 16:40:21
date last changed
2017-11-05 03:15:12
@article{80ed9036-cece-4dcf-beb9-2464142977f1,
  abstract     = {A simple and efficient approach for profiling the greenness of high performance liquid chromatography (HPLC) methods is presented. This environmental assessment tool (EAT) takes into consideration the environmental, health and safety issues for all solvents involved in the chromatographic method, and calculates a total score that can be used for comparison of the greenness of different methods. A software, HPLC-EAT, has been designed to facilitate the calculation and can be downloaded free of charge at http://www.biotek.lu.se/hplc-eat/. HPLC-EAT was successfully applied for a set of different HPLC methods from the literature, including both analytical and preparative chromatography. The performance of the tool was validated and it was further combined with another free software Eco-solvent tool to perform life cycle assessments of waste disposal options of distillation or incineration. HPLC-EAT can be routinely used in method development to calculate the greenness beside the conventional standards of accuracy, robustness and reproducibility.},
  author       = {Gaber, Yasser and Törnvall, Ulrika and Kumar, M A and Amin, Magdy Ali and Hatti-Kaul, Rajni},
  issn         = {1463-9270},
  language     = {eng},
  number       = {8},
  pages        = {2021--2025},
  publisher    = {Royal Society of Chemistry},
  series       = {Green Chemistry},
  title        = {HPLC-EAT (Environmental Assessment Tool): A tool for profiling safety, health and environmental impacts of liquid chromatography methods},
  url          = {http://dx.doi.org/10.1039/c0gc00667j},
  volume       = {13},
  year         = {2011},
}