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Sequelae of Treatment in Long-term Survivors of Testis Cancer

Abouassaly, Robert; Fossa, Sophie D.; Giwercman, Aleksander LU ; Kollmannsberger, Christian; Motzer, Robert J.; Schmoll, Hans-Joachim and Sternberg, Cora N. (2011) In European Urology 60(3). p.516-526
Abstract
Context: Testicular cancer patients are often diagnosed at a young age, and because of the advances in the treatment of this disease, the vast majority have a normal life expectancy after therapy. Thus, recognition of the long-term sequelae of treatment (ie, surgery, radiation therapy, and chemotherapy) is particularly important in these patients. Objective: To review the adverse effects and the risk of secondary malignancy in long-term survivors of testicular cancer. Evidence acquisition: We conducted a Medline search to identify original articles and reviews on the long-term effects of testicular cancer treatment. Although the search included articles from January 1948 to February 2011, the majority of the included articles were... (More)
Context: Testicular cancer patients are often diagnosed at a young age, and because of the advances in the treatment of this disease, the vast majority have a normal life expectancy after therapy. Thus, recognition of the long-term sequelae of treatment (ie, surgery, radiation therapy, and chemotherapy) is particularly important in these patients. Objective: To review the adverse effects and the risk of secondary malignancy in long-term survivors of testicular cancer. Evidence acquisition: We conducted a Medline search to identify original articles and reviews on the long-term effects of testicular cancer treatment. Although the search included articles from January 1948 to February 2011, the majority of the included articles were published in the last two decades. Evidence synthesis: All studies examining the long-term sequelae of treatment in testicular cancer are retrospective in nature, with most classified as cohort, case-control, and/or epidemiologic studies. Given that no standardized method of reporting long-term complications exists, evidence synthesis is limited. Conclusions: Recent evidence suggests an increased risk of cardiovascular disease, neurotoxicity, and mild reductions in renal function in survivors of testicular cancer. Treatment of testicular malignancy can also negatively affect gonadal function and fertility and has been shown to result in an increased risk of solid malignancy and leukemia. (C) 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Testicular neoplasms, Neoplasms, Germ cell and embryonal
in
European Urology
volume
60
issue
3
pages
516 - 526
publisher
Elsevier
external identifiers
  • wos:000293283100030
  • scopus:79960972513
ISSN
1873-7560
DOI
10.1016/j.eururo.2011.05.055
language
English
LU publication?
yes
id
c269454e-6ac6-4f46-9f34-d44fa939afb4 (old id 2072327)
date added to LUP
2011-09-02 08:31:24
date last changed
2017-11-05 04:13:41
@article{c269454e-6ac6-4f46-9f34-d44fa939afb4,
  abstract     = {Context: Testicular cancer patients are often diagnosed at a young age, and because of the advances in the treatment of this disease, the vast majority have a normal life expectancy after therapy. Thus, recognition of the long-term sequelae of treatment (ie, surgery, radiation therapy, and chemotherapy) is particularly important in these patients. Objective: To review the adverse effects and the risk of secondary malignancy in long-term survivors of testicular cancer. Evidence acquisition: We conducted a Medline search to identify original articles and reviews on the long-term effects of testicular cancer treatment. Although the search included articles from January 1948 to February 2011, the majority of the included articles were published in the last two decades. Evidence synthesis: All studies examining the long-term sequelae of treatment in testicular cancer are retrospective in nature, with most classified as cohort, case-control, and/or epidemiologic studies. Given that no standardized method of reporting long-term complications exists, evidence synthesis is limited. Conclusions: Recent evidence suggests an increased risk of cardiovascular disease, neurotoxicity, and mild reductions in renal function in survivors of testicular cancer. Treatment of testicular malignancy can also negatively affect gonadal function and fertility and has been shown to result in an increased risk of solid malignancy and leukemia. (C) 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved.},
  author       = {Abouassaly, Robert and Fossa, Sophie D. and Giwercman, Aleksander and Kollmannsberger, Christian and Motzer, Robert J. and Schmoll, Hans-Joachim and Sternberg, Cora N.},
  issn         = {1873-7560},
  keyword      = {Testicular neoplasms,Neoplasms,Germ cell and embryonal},
  language     = {eng},
  number       = {3},
  pages        = {516--526},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Sequelae of Treatment in Long-term Survivors of Testis Cancer},
  url          = {http://dx.doi.org/10.1016/j.eururo.2011.05.055},
  volume       = {60},
  year         = {2011},
}