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Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Haugen, Ida K.; Englund, Martin LU ; Aliabadi, Piran; Niu, Jingbo; Clancy, Margaret; Kvien, Tore K. and Felson, David T. (2011) In Annals of the Rheumatic Diseases 70(9). p.1581-1586
Abstract
Objectives To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Methods Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren-Lawrence grade (KLG)>= 2, erosive HOA as KLG >= 2 plus erosion and symptomatic HOA as KLG >= 2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as >= 1 affected joint. The prevalence was age-standardised (US 2000 Population 40-84 years). Results Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly... (More)
Objectives To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Methods Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren-Lawrence grade (KLG)>= 2, erosive HOA as KLG >= 2 plus erosion and symptomatic HOA as KLG >= 2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as >= 1 affected joint. The prevalence was age-standardised (US 2000 Population 40-84 years). Results Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly higher in women (44.2%) than men (37.7%), whereas the age-standardised prevalence of erosive and symptomatic OA was much higher in women (9.9% vs 3.3%, and 15.9% vs 8.2%). The crude incidence of HOA over 9-year follow-up was similar in women (34.6%) and men (33.7%), whereas the majority of those women (96.4%) and men (91.4%) with HOA at baseline showed progression during follow-up. Incident metacarpophalangeal and wrist OA were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive HOA at baseline (as opposed to those without HOA), and was more frequent in women (17.3%) than men (9.6%). Conclusions The usual female predominance of prevalent and incident HOA was less clear for radiographic HOA than for symptomatic and erosive HOA. With an ageing population, the impact of HOA will further increase. (Less)
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Contribution to journal
publication status
published
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in
Annals of the Rheumatic Diseases
volume
70
issue
9
pages
1581 - 1586
publisher
British Medical Association
external identifiers
  • wos:000293275600011
  • scopus:80051475045
ISSN
1468-2060
DOI
10.1136/ard.2011.150078
language
English
LU publication?
yes
id
ba11c72f-6b99-489e-aada-f43867799241 (old id 2072481)
date added to LUP
2011-09-02 08:32:21
date last changed
2017-11-19 03:53:53
@article{ba11c72f-6b99-489e-aada-f43867799241,
  abstract     = {Objectives To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Methods Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren-Lawrence grade (KLG)>= 2, erosive HOA as KLG >= 2 plus erosion and symptomatic HOA as KLG >= 2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as >= 1 affected joint. The prevalence was age-standardised (US 2000 Population 40-84 years). Results Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly higher in women (44.2%) than men (37.7%), whereas the age-standardised prevalence of erosive and symptomatic OA was much higher in women (9.9% vs 3.3%, and 15.9% vs 8.2%). The crude incidence of HOA over 9-year follow-up was similar in women (34.6%) and men (33.7%), whereas the majority of those women (96.4%) and men (91.4%) with HOA at baseline showed progression during follow-up. Incident metacarpophalangeal and wrist OA were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive HOA at baseline (as opposed to those without HOA), and was more frequent in women (17.3%) than men (9.6%). Conclusions The usual female predominance of prevalent and incident HOA was less clear for radiographic HOA than for symptomatic and erosive HOA. With an ageing population, the impact of HOA will further increase.},
  author       = {Haugen, Ida K. and Englund, Martin and Aliabadi, Piran and Niu, Jingbo and Clancy, Margaret and Kvien, Tore K. and Felson, David T.},
  issn         = {1468-2060},
  language     = {eng},
  number       = {9},
  pages        = {1581--1586},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study},
  url          = {http://dx.doi.org/10.1136/ard.2011.150078},
  volume       = {70},
  year         = {2011},
}