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Interferon-gamma inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism

Strickertsson, Jesper A. B.; Dossing, Kristina B. V.; Aabakke, Anna J. M.; Nilsson, Hans-Olof LU ; Hansen, Thomas V. O.; Knigge, Ulrich; Kjaer, Andreas; Wadström, Torkel LU and Friis-Hansen, Lennart (2011) In World Journal of Gastroenterology 17(26). p.3117-3125
Abstract
AIM: To investigate if and how the proinflammatory cytokine interferon gamma (IFN gamma) affects ghrelin expression in mice. METHODS: The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were examined in wild-type mice and mice infected with Helicobacter pylori (H. pylon). Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFN gamma alone, mice were given a subcutaneous infusion of IFN gamma for 7 d. Finally, the influence of IFN gamma, and somatostatin on the ghrelin promoter was characterized. RESULTS: H. pylori infection was associated with a 50% reduction in ghrelin expression and plasma... (More)
AIM: To investigate if and how the proinflammatory cytokine interferon gamma (IFN gamma) affects ghrelin expression in mice. METHODS: The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were examined in wild-type mice and mice infected with Helicobacter pylori (H. pylon). Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFN gamma alone, mice were given a subcutaneous infusion of IFN gamma for 7 d. Finally, the influence of IFN gamma, and somatostatin on the ghrelin promoter was characterized. RESULTS: H. pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration. Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models. Subcutaneous infusion of IFN gamma suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations. Finally, we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFN gamma. CONCLUSION: Gastric infection and inflammation is associated with increased IFN gamma expression and reduced ghrelin expression. IFN gamma does not directly control ghrelin expression but inhibits it indirectly via somatostatin. (C) 2011 Baishideng. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ghrelin, Interferon-gamma, Somatostatin, Inflammatory diseases, Helicobacter pylori
in
World Journal of Gastroenterology
volume
17
issue
26
pages
3117 - 3125
publisher
WJG Press
external identifiers
  • wos:000292939800006
  • scopus:79961045636
ISSN
1007-9327
DOI
10.3748/wjg.v17.i26.3117
language
English
LU publication?
yes
id
981d07eb-7ea7-41be-9591-0aa1637c0ecd (old id 2072536)
date added to LUP
2011-09-02 08:32:28
date last changed
2017-01-22 03:15:47
@article{981d07eb-7ea7-41be-9591-0aa1637c0ecd,
  abstract     = {AIM: To investigate if and how the proinflammatory cytokine interferon gamma (IFN gamma) affects ghrelin expression in mice. METHODS: The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were examined in wild-type mice and mice infected with Helicobacter pylori (H. pylon). Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFN gamma alone, mice were given a subcutaneous infusion of IFN gamma for 7 d. Finally, the influence of IFN gamma, and somatostatin on the ghrelin promoter was characterized. RESULTS: H. pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration. Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models. Subcutaneous infusion of IFN gamma suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations. Finally, we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFN gamma. CONCLUSION: Gastric infection and inflammation is associated with increased IFN gamma expression and reduced ghrelin expression. IFN gamma does not directly control ghrelin expression but inhibits it indirectly via somatostatin. (C) 2011 Baishideng. All rights reserved.},
  author       = {Strickertsson, Jesper A. B. and Dossing, Kristina B. V. and Aabakke, Anna J. M. and Nilsson, Hans-Olof and Hansen, Thomas V. O. and Knigge, Ulrich and Kjaer, Andreas and Wadström, Torkel and Friis-Hansen, Lennart},
  issn         = {1007-9327},
  keyword      = {Ghrelin,Interferon-gamma,Somatostatin,Inflammatory diseases,Helicobacter pylori},
  language     = {eng},
  number       = {26},
  pages        = {3117--3125},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Interferon-gamma inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism},
  url          = {http://dx.doi.org/10.3748/wjg.v17.i26.3117},
  volume       = {17},
  year         = {2011},
}