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Population-based register study of children born in Sweden from 1997 to 2014 showed an increase in rickets during infancy

Högberg, Ulf ; Winbo, Jenny and Fellman, Vineta LU (2019) In Acta Paediatrica, International Journal of Paediatrics
Abstract

Aim: This population-based study assessed the incidence of rickets in infants up to age of one born in Sweden from 1997 to 2014. We also examined maternal and perinatal factors and co-morbidity. Methods: We used Swedish National Board of Health and Welfare registers and data from Statistics Sweden. The outcome measure was an International Classification of Diseases, Tenth Revision, code for rickets. Results: There were 273 cases of rickets, with an incidence of 14.7 per 100 000 and a 10-fold incidence increase between 1997 and 2014. The majority (78.4%) were born preterm, half were small-for-gestational age (SGA) (birthweight <10th percentile), 4.8% were born to Asian-born mothers and 3.5% to African-born mothers. The adjusted odds... (More)

Aim: This population-based study assessed the incidence of rickets in infants up to age of one born in Sweden from 1997 to 2014. We also examined maternal and perinatal factors and co-morbidity. Methods: We used Swedish National Board of Health and Welfare registers and data from Statistics Sweden. The outcome measure was an International Classification of Diseases, Tenth Revision, code for rickets. Results: There were 273 cases of rickets, with an incidence of 14.7 per 100 000 and a 10-fold incidence increase between 1997 and 2014. The majority (78.4%) were born preterm, half were small-for-gestational age (SGA) (birthweight <10th percentile), 4.8% were born to Asian-born mothers and 3.5% to African-born mothers. The adjusted odds ratios by birth week were 182 (95% CI: 121–272) before 32 weeks and 10.8 (95% CI: 6.72–17.4) by 32–36 weeks. Preterm infants with necrotising enterocolitis had very high odds for rickets and so did SGA term-born infants and those born to African-born mothers. The odds for rickets among preterm infants increased considerably during the later years. Conclusion: Rickets increased 10-fold in Sweden from 1997 to 2014 and was mainly associated with prematurity, SGA and foreign-born mothers. Possible reasons may include increased preterm survival rates and improved clinical detection and registration.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Incidence, Infants, Metabolic bone disease, Rickets, Vitamin D deficiency
in
Acta Paediatrica, International Journal of Paediatrics
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85066632302
  • pmid:31050835
ISSN
0803-5253
DOI
10.1111/apa.14835
language
English
LU publication?
yes
id
2080493b-f9c0-44a3-b345-9ed050f1f548
date added to LUP
2019-06-24 12:24:48
date last changed
2019-07-09 04:49:15
@article{2080493b-f9c0-44a3-b345-9ed050f1f548,
  abstract     = {<p>Aim: This population-based study assessed the incidence of rickets in infants up to age of one born in Sweden from 1997 to 2014. We also examined maternal and perinatal factors and co-morbidity. Methods: We used Swedish National Board of Health and Welfare registers and data from Statistics Sweden. The outcome measure was an International Classification of Diseases, Tenth Revision, code for rickets. Results: There were 273 cases of rickets, with an incidence of 14.7 per 100 000 and a 10-fold incidence increase between 1997 and 2014. The majority (78.4%) were born preterm, half were small-for-gestational age (SGA) (birthweight &lt;10th percentile), 4.8% were born to Asian-born mothers and 3.5% to African-born mothers. The adjusted odds ratios by birth week were 182 (95% CI: 121–272) before 32 weeks and 10.8 (95% CI: 6.72–17.4) by 32–36 weeks. Preterm infants with necrotising enterocolitis had very high odds for rickets and so did SGA term-born infants and those born to African-born mothers. The odds for rickets among preterm infants increased considerably during the later years. Conclusion: Rickets increased 10-fold in Sweden from 1997 to 2014 and was mainly associated with prematurity, SGA and foreign-born mothers. Possible reasons may include increased preterm survival rates and improved clinical detection and registration.</p>},
  author       = {Högberg, Ulf and Winbo, Jenny and Fellman, Vineta},
  issn         = {0803-5253},
  language     = {eng},
  month        = {05},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Population-based register study of children born in Sweden from 1997 to 2014 showed an increase in rickets during infancy},
  url          = {http://dx.doi.org/10.1111/apa.14835},
  doi          = {10.1111/apa.14835},
  year         = {2019},
}