Population-based register study of children born in Sweden from 1997 to 2014 showed an increase in rickets during infancy
Högberg, Ulf ; Winbo, Jenny and Fellman, Vineta LU
(2019)
In Acta Paediatrica, International Journal of Paediatrics
108(11).
p.2034-2040
- Abstract
Aim: This population-based study assessed the incidence of rickets in infants up to age of one born in Sweden from 1997 to 2014. We also examined maternal and perinatal factors and co-morbidity. Methods: We used Swedish National Board of Health and Welfare registers and data from Statistics Sweden. The outcome measure was an International Classification of Diseases, Tenth Revision, code for rickets. Results: There were 273 cases of rickets, with an incidence of 14.7 per 100 000 and a 10-fold incidence increase between 1997 and 2014. The majority (78.4%) were born preterm, half were small-for-gestational age (SGA) (birthweight <10th percentile), 4.8% were born to Asian-born mothers and 3.5% to African-born mothers. The adjusted odds... (More)
Aim: This population-based study assessed the incidence of rickets in infants up to age of one born in Sweden from 1997 to 2014. We also examined maternal and perinatal factors and co-morbidity. Methods: We used Swedish National Board of Health and Welfare registers and data from Statistics Sweden. The outcome measure was an International Classification of Diseases, Tenth Revision, code for rickets. Results: There were 273 cases of rickets, with an incidence of 14.7 per 100 000 and a 10-fold incidence increase between 1997 and 2014. The majority (78.4%) were born preterm, half were small-for-gestational age (SGA) (birthweight <10th percentile), 4.8% were born to Asian-born mothers and 3.5% to African-born mothers. The adjusted odds ratios by birth week were 182 (95% CI: 121–272) before 32 weeks and 10.8 (95% CI: 6.72–17.4) by 32–36 weeks. Preterm infants with necrotising enterocolitis had very high odds for rickets and so did SGA term-born infants and those born to African-born mothers. The odds for rickets among preterm infants increased considerably during the later years. Conclusion: Rickets increased 10-fold in Sweden from 1997 to 2014 and was mainly associated with prematurity, SGA and foreign-born mothers. Possible reasons may include increased preterm survival rates and improved clinical detection and registration.
(Less)
- author
- Högberg, Ulf
; Winbo, Jenny
and Fellman, Vineta
LU
- organization
- publishing date
- 2019-05-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Incidence, Infants, Metabolic bone disease, Rickets, Vitamin D deficiency
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 108
- issue
- 11
- pages
- 2034 - 2040
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:31050835
- scopus:85066632302
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.14835
- language
- English
- LU publication?
- yes
- id
- 2080493b-f9c0-44a3-b345-9ed050f1f548
- date added to LUP
- 2019-06-24 12:24:48
- date last changed
- 2024-04-16 11:45:20
@article{2080493b-f9c0-44a3-b345-9ed050f1f548,
abstract = {{<p>Aim: This population-based study assessed the incidence of rickets in infants up to age of one born in Sweden from 1997 to 2014. We also examined maternal and perinatal factors and co-morbidity. Methods: We used Swedish National Board of Health and Welfare registers and data from Statistics Sweden. The outcome measure was an International Classification of Diseases, Tenth Revision, code for rickets. Results: There were 273 cases of rickets, with an incidence of 14.7 per 100 000 and a 10-fold incidence increase between 1997 and 2014. The majority (78.4%) were born preterm, half were small-for-gestational age (SGA) (birthweight <10th percentile), 4.8% were born to Asian-born mothers and 3.5% to African-born mothers. The adjusted odds ratios by birth week were 182 (95% CI: 121–272) before 32 weeks and 10.8 (95% CI: 6.72–17.4) by 32–36 weeks. Preterm infants with necrotising enterocolitis had very high odds for rickets and so did SGA term-born infants and those born to African-born mothers. The odds for rickets among preterm infants increased considerably during the later years. Conclusion: Rickets increased 10-fold in Sweden from 1997 to 2014 and was mainly associated with prematurity, SGA and foreign-born mothers. Possible reasons may include increased preterm survival rates and improved clinical detection and registration.</p>}},
author = {{Högberg, Ulf and Winbo, Jenny and Fellman, Vineta}},
issn = {{0803-5253}},
keywords = {{Incidence; Infants; Metabolic bone disease; Rickets; Vitamin D deficiency}},
language = {{eng}},
month = {{05}},
number = {{11}},
pages = {{2034--2040}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Population-based register study of children born in Sweden from 1997 to 2014 showed an increase in rickets during infancy}},
url = {{http://dx.doi.org/10.1111/apa.14835}},
doi = {{10.1111/apa.14835}},
volume = {{108}},
year = {{2019}},
}