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Multifocal electroretinography (mfERG) in insulin dependent diabetics with and without clinically apparent retinopathy

Tyrberg, Maria LU ; Ponjavic, Vesna LU and Lövestam Adrian, Monica LU (2005) In Documenta Ophthalmologica 110(2-3). p.137-143
Abstract
Purpose: To Study the retinal function, using multifocal electroretinography (mfERG), in diabetic patients with mild and moderate retinopathy, and in diabetics without clinically apparent retinopathy. Methods: Thirty-one patients with insulin dependent diabetes mellitus, eleven without any clinically apparent retinopathy, twelve with mild retinopathy and eight with moderate retinopathy, were studied. Ophthalmologic examination included testing Of Visual acuity, fundus inspection, fundus photography and mfERG. Sixteen subjects without eye disease and with normal visual acuity were used as controls for comparison of mfERG results. Results: The patients had a mean diabetes duration of 23 +/- 9 years. All patients and controls had a visual... (More)
Purpose: To Study the retinal function, using multifocal electroretinography (mfERG), in diabetic patients with mild and moderate retinopathy, and in diabetics without clinically apparent retinopathy. Methods: Thirty-one patients with insulin dependent diabetes mellitus, eleven without any clinically apparent retinopathy, twelve with mild retinopathy and eight with moderate retinopathy, were studied. Ophthalmologic examination included testing Of Visual acuity, fundus inspection, fundus photography and mfERG. Sixteen subjects without eye disease and with normal visual acuity were used as controls for comparison of mfERG results. Results: The patients had a mean diabetes duration of 23 +/- 9 years. All patients and controls had a visual acuity of 1.0. In the first order component of the mfERG there were significantly higher ring amplitudes in the diabetics compared to the controls (p=0.001). In the second-order component of the mfERG, there was a significantly prolonged implicit time in the diabetics who had retinopathy compared to those without any retinopathy (p=0.026). The third positive waveform in the ring amplitudes of the second-order component, were absent in 15/31 of patients with diabetes, but were easily distinguished in all the controls; p < 0.001. This waveform was absent in 6/11 patients without retinopathy. Conclusion: Patients with insulin dependent diabetes have specific abnormalities in both the First and the second-order component of the mfERG. These abnormalities reflect both vascular changes in the retina and, probably simultaneously, pathology in inner retinal function, also in the diabetics without clinically apparent retinopathy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insulin dependent diabetes mellitus, multifocal electroretinogram, retinal dysfunction
in
Documenta Ophthalmologica
volume
110
issue
2-3
pages
137 - 143
publisher
Springer
external identifiers
  • wos:000236706100001
  • scopus:28844478426
ISSN
1573-2622
DOI
10.1007/s10633-005-4187-5
language
English
LU publication?
yes
id
1b5a6b92-6c74-4210-842d-58b0fe1e5e99 (old id 208471)
date added to LUP
2007-08-20 10:23:07
date last changed
2017-09-24 03:46:31
@article{1b5a6b92-6c74-4210-842d-58b0fe1e5e99,
  abstract     = {Purpose: To Study the retinal function, using multifocal electroretinography (mfERG), in diabetic patients with mild and moderate retinopathy, and in diabetics without clinically apparent retinopathy. Methods: Thirty-one patients with insulin dependent diabetes mellitus, eleven without any clinically apparent retinopathy, twelve with mild retinopathy and eight with moderate retinopathy, were studied. Ophthalmologic examination included testing Of Visual acuity, fundus inspection, fundus photography and mfERG. Sixteen subjects without eye disease and with normal visual acuity were used as controls for comparison of mfERG results. Results: The patients had a mean diabetes duration of 23 +/- 9 years. All patients and controls had a visual acuity of 1.0. In the first order component of the mfERG there were significantly higher ring amplitudes in the diabetics compared to the controls (p=0.001). In the second-order component of the mfERG, there was a significantly prolonged implicit time in the diabetics who had retinopathy compared to those without any retinopathy (p=0.026). The third positive waveform in the ring amplitudes of the second-order component, were absent in 15/31 of patients with diabetes, but were easily distinguished in all the controls; p &lt; 0.001. This waveform was absent in 6/11 patients without retinopathy. Conclusion: Patients with insulin dependent diabetes have specific abnormalities in both the First and the second-order component of the mfERG. These abnormalities reflect both vascular changes in the retina and, probably simultaneously, pathology in inner retinal function, also in the diabetics without clinically apparent retinopathy.},
  author       = {Tyrberg, Maria and Ponjavic, Vesna and Lövestam Adrian, Monica},
  issn         = {1573-2622},
  keyword      = {insulin dependent diabetes mellitus,multifocal electroretinogram,retinal dysfunction},
  language     = {eng},
  number       = {2-3},
  pages        = {137--143},
  publisher    = {Springer},
  series       = {Documenta Ophthalmologica},
  title        = {Multifocal electroretinography (mfERG) in insulin dependent diabetics with and without clinically apparent retinopathy},
  url          = {http://dx.doi.org/10.1007/s10633-005-4187-5},
  volume       = {110},
  year         = {2005},
}