Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes
(2013) In Journal of Applied Physiology 115(10). p.1450-1456- Abstract
- Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting beta(2)-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15... (More)
- Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting beta(2)-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 +/- 8% (SD) on placebo was reduced to 8 +/- 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall <10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions (P < 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 +/- 495 pg/mu mol creatinine after placebo vs. 315 +/- 523 pg/mu mol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4274268
- author
- Simpson, A. J. ; Tufvesson, Ellen LU ; Anderson, S. D. ; Romer, L. M. ; Bjermer, Leif LU and Kippelen, P.
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- exercise-induced bronchoconstriction, epithelial injury, inhaled, beta(2)-agonist, Clara cell
- in
- Journal of Applied Physiology
- volume
- 115
- issue
- 10
- pages
- 1450 - 1456
- publisher
- American Physiological Society
- external identifiers
-
- wos:000327398600005
- scopus:84888391102
- pmid:24030662
- ISSN
- 1522-1601
- DOI
- 10.1152/japplphysiol.00716.2013
- language
- English
- LU publication?
- yes
- id
- 2087defd-5884-4519-8a04-c8c55fae24ee (old id 4274268)
- date added to LUP
- 2016-04-01 10:52:17
- date last changed
- 2022-01-26 03:17:50
@article{2087defd-5884-4519-8a04-c8c55fae24ee,
abstract = {{Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting beta(2)-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 +/- 8% (SD) on placebo was reduced to 8 +/- 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall <10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions (P < 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 +/- 495 pg/mu mol creatinine after placebo vs. 315 +/- 523 pg/mu mol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes.}},
author = {{Simpson, A. J. and Tufvesson, Ellen and Anderson, S. D. and Romer, L. M. and Bjermer, Leif and Kippelen, P.}},
issn = {{1522-1601}},
keywords = {{exercise-induced bronchoconstriction; epithelial injury; inhaled; beta(2)-agonist; Clara cell}},
language = {{eng}},
number = {{10}},
pages = {{1450--1456}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes}},
url = {{http://dx.doi.org/10.1152/japplphysiol.00716.2013}},
doi = {{10.1152/japplphysiol.00716.2013}},
volume = {{115}},
year = {{2013}},
}