Advanced

Genetic prediction of future type 2 diabetes

Lyssenko, Valeriya LU ; Almgren, Peter LU ; Anevski, Dragi LU ; Orho-Melander, Marju LU ; Sjögren, Marketa LU ; Saloranta, C; Tuomi, T and Groop, Leif LU (2005) In PLoS Medicine 2(12). p.1299-1308
Abstract
Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G > A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. After a median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developing T2D was 1.7 (95% confidence interval [Cl] 1.1-2.7)... (More)
Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G > A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. After a median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developing T2D was 1.7 (95% confidence interval [Cl] 1.1-2.7) for the PPARG PP genotype, 1.5 (95% Cl 1.0-2.2) for the CAPN10 SNP44 TT genotype, and 2.6 (95% Cl 1.5-4.5) for the combination of PPARG and CAPN10 risk genotypes. In individuals with fasting plasma glucose >= 5.6 mmol/l and body mass index >= 30 kg/m(2), the hazard ratio increased to 21.2 (95% Cl 8.751.4) for the combination of the PPARG PP and CAPN10 SNP43/44 GG/17 genotypes as compared to those with the low-risk genotypes with normal fasting plasma glucose and body mass index < 30 kg/m(2). Conclusion We demonstrate in a large prospective study that variants in the PPARG and CAPN10 genes predict future T2D. Genetic testing might become a future approach to identify individuals at risk of developing T2D. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Medicine
volume
2
issue
12
pages
1299 - 1308
publisher
Public Library of Science
external identifiers
  • wos:000234714700018
  • scopus:29644438528
ISSN
1549-1676
DOI
10.1371/journal.pmed.0020345
language
English
LU publication?
yes
id
cfa1ea60-0947-4afc-8889-dcc4cb364c82 (old id 209737)
date added to LUP
2007-08-14 09:54:28
date last changed
2017-10-08 03:30:06
@article{cfa1ea60-0947-4afc-8889-dcc4cb364c82,
  abstract     = {Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G &gt; A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. After a median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developing T2D was 1.7 (95% confidence interval [Cl] 1.1-2.7) for the PPARG PP genotype, 1.5 (95% Cl 1.0-2.2) for the CAPN10 SNP44 TT genotype, and 2.6 (95% Cl 1.5-4.5) for the combination of PPARG and CAPN10 risk genotypes. In individuals with fasting plasma glucose &gt;= 5.6 mmol/l and body mass index &gt;= 30 kg/m(2), the hazard ratio increased to 21.2 (95% Cl 8.751.4) for the combination of the PPARG PP and CAPN10 SNP43/44 GG/17 genotypes as compared to those with the low-risk genotypes with normal fasting plasma glucose and body mass index &lt; 30 kg/m(2). Conclusion We demonstrate in a large prospective study that variants in the PPARG and CAPN10 genes predict future T2D. Genetic testing might become a future approach to identify individuals at risk of developing T2D.},
  author       = {Lyssenko, Valeriya and Almgren, Peter and Anevski, Dragi and Orho-Melander, Marju and Sjögren, Marketa and Saloranta, C and Tuomi, T and Groop, Leif},
  issn         = {1549-1676},
  language     = {eng},
  number       = {12},
  pages        = {1299--1308},
  publisher    = {Public Library of Science},
  series       = {PLoS Medicine},
  title        = {Genetic prediction of future type 2 diabetes},
  url          = {http://dx.doi.org/10.1371/journal.pmed.0020345},
  volume       = {2},
  year         = {2005},
}