Genetic prediction of future type 2 diabetes
(2005) In PLoS Medicine 2(12). p.1299-1308- Abstract
- Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G > A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. After a median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developing T2D was 1.7 (95% confidence interval [Cl] 1.1-2.7)... (More)
- Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G > A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. After a median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developing T2D was 1.7 (95% confidence interval [Cl] 1.1-2.7) for the PPARG PP genotype, 1.5 (95% Cl 1.0-2.2) for the CAPN10 SNP44 TT genotype, and 2.6 (95% Cl 1.5-4.5) for the combination of PPARG and CAPN10 risk genotypes. In individuals with fasting plasma glucose >= 5.6 mmol/l and body mass index >= 30 kg/m(2), the hazard ratio increased to 21.2 (95% Cl 8.751.4) for the combination of the PPARG PP and CAPN10 SNP43/44 GG/17 genotypes as compared to those with the low-risk genotypes with normal fasting plasma glucose and body mass index < 30 kg/m(2). Conclusion We demonstrate in a large prospective study that variants in the PPARG and CAPN10 genes predict future T2D. Genetic testing might become a future approach to identify individuals at risk of developing T2D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/209737
- author
- Lyssenko, Valeriya LU ; Almgren, Peter LU ; Anevski, Dragi LU ; Orho-Melander, Marju LU ; Sjögren, Marketa LU ; Saloranta, C ; Tuomi, T and Groop, Leif LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Medicine
- volume
- 2
- issue
- 12
- pages
- 1299 - 1308
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000234714700018
- scopus:29644438528
- ISSN
- 1549-1676
- DOI
- 10.1371/journal.pmed.0020345
- language
- English
- LU publication?
- yes
- id
- cfa1ea60-0947-4afc-8889-dcc4cb364c82 (old id 209737)
- date added to LUP
- 2016-04-01 11:51:21
- date last changed
- 2024-05-06 19:17:34
@article{cfa1ea60-0947-4afc-8889-dcc4cb364c82, abstract = {{Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G > A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. After a median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developing T2D was 1.7 (95% confidence interval [Cl] 1.1-2.7) for the PPARG PP genotype, 1.5 (95% Cl 1.0-2.2) for the CAPN10 SNP44 TT genotype, and 2.6 (95% Cl 1.5-4.5) for the combination of PPARG and CAPN10 risk genotypes. In individuals with fasting plasma glucose >= 5.6 mmol/l and body mass index >= 30 kg/m(2), the hazard ratio increased to 21.2 (95% Cl 8.751.4) for the combination of the PPARG PP and CAPN10 SNP43/44 GG/17 genotypes as compared to those with the low-risk genotypes with normal fasting plasma glucose and body mass index < 30 kg/m(2). Conclusion We demonstrate in a large prospective study that variants in the PPARG and CAPN10 genes predict future T2D. Genetic testing might become a future approach to identify individuals at risk of developing T2D.}}, author = {{Lyssenko, Valeriya and Almgren, Peter and Anevski, Dragi and Orho-Melander, Marju and Sjögren, Marketa and Saloranta, C and Tuomi, T and Groop, Leif}}, issn = {{1549-1676}}, language = {{eng}}, number = {{12}}, pages = {{1299--1308}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS Medicine}}, title = {{Genetic prediction of future type 2 diabetes}}, url = {{https://lup.lub.lu.se/search/files/2672855/626015.pdf}}, doi = {{10.1371/journal.pmed.0020345}}, volume = {{2}}, year = {{2005}}, }