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An international dosimetry exchange for boron neutron capture therapy, Part I: Absorbed dose measurements

Binns, P J; Riley, K J; Harling, O K; Kiger, W S; Munck af Rosenschöld, Per LU ; Giusti, V; Capala, J; Skold, K; Auterinen, I and Seren, T, et al. (2005) In Medical Physics 32(12). p.3729-3736
Abstract
An international collaboration was organized to undertake a dosimetry exchange to enable the future combination of clinical data from different centers conducting neutron capture therapy trials. As a first step (Part I) the dosimetry group from the Americas, represented by MIT, visited the clinical centers at Studsvik (Sweden), VTT Espoo (Finland), and the Nuclear Research Institute (NRI) at Rez (Czech Republic). A combined VTT/NRI group reciprocated with a visit to MIT. Each participant performed a series of dosimetry measurements under equivalent irradiation conditions using methods appropriate to their clinical protocols. This entailed in-air measurements and dose versus depth measurements in a large water phantom. Thermal neutron flux... (More)
An international collaboration was organized to undertake a dosimetry exchange to enable the future combination of clinical data from different centers conducting neutron capture therapy trials. As a first step (Part I) the dosimetry group from the Americas, represented by MIT, visited the clinical centers at Studsvik (Sweden), VTT Espoo (Finland), and the Nuclear Research Institute (NRI) at Rez (Czech Republic). A combined VTT/NRI group reciprocated with a visit to MIT. Each participant performed a series of dosimetry measurements under equivalent irradiation conditions using methods appropriate to their clinical protocols. This entailed in-air measurements and dose versus depth measurements in a large water phantom. Thermal neutron flux as well as fast neutron and photon absorbed dose rates were measured. Satisfactory agreement in determining absorbed dose within the experimental uncertainties was obtained between the different groups although the measurement uncertainties are large, ranging between 3% and 30% depending upon the dose component and the depth of measurement. To improve the precision in the specification of absorbed dose amongst the participants, the individually measured dose components were normalized to the results from a single method. Assuming a boron concentration of 15 mu g g(-1) that is typical of concentrations realized clinically with the boron delivery compound boronophenylalanine-fructose, systematic discrepancies in the specification of the total biologically weighted dose of up to 10% were apparent between the different groups. The results from these measurements will be used in future to normalize treatment plan calculations between the different clinical dosimetry protocols as Part II of this study. (c) 2005 American Association of Physicists in Medicine. (Less)
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published
subject
keywords
dosimetry intercomparison, BNCT, thermal neutrons
in
Medical Physics
volume
32
issue
12
pages
3729 - 3736
publisher
American Association of Physicists in Medicine
external identifiers
  • wos:000234643700024
  • pmid:16475772
  • scopus:33644997435
ISSN
0094-2405
DOI
10.1118/1.2132572
language
English
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yes
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767dc184-83d0-4b6c-b7ed-42930f9d28b0 (old id 209809)
date added to LUP
2007-08-02 12:10:42
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2017-04-16 04:13:45
@article{767dc184-83d0-4b6c-b7ed-42930f9d28b0,
  abstract     = {An international collaboration was organized to undertake a dosimetry exchange to enable the future combination of clinical data from different centers conducting neutron capture therapy trials. As a first step (Part I) the dosimetry group from the Americas, represented by MIT, visited the clinical centers at Studsvik (Sweden), VTT Espoo (Finland), and the Nuclear Research Institute (NRI) at Rez (Czech Republic). A combined VTT/NRI group reciprocated with a visit to MIT. Each participant performed a series of dosimetry measurements under equivalent irradiation conditions using methods appropriate to their clinical protocols. This entailed in-air measurements and dose versus depth measurements in a large water phantom. Thermal neutron flux as well as fast neutron and photon absorbed dose rates were measured. Satisfactory agreement in determining absorbed dose within the experimental uncertainties was obtained between the different groups although the measurement uncertainties are large, ranging between 3% and 30% depending upon the dose component and the depth of measurement. To improve the precision in the specification of absorbed dose amongst the participants, the individually measured dose components were normalized to the results from a single method. Assuming a boron concentration of 15 mu g g(-1) that is typical of concentrations realized clinically with the boron delivery compound boronophenylalanine-fructose, systematic discrepancies in the specification of the total biologically weighted dose of up to 10% were apparent between the different groups. The results from these measurements will be used in future to normalize treatment plan calculations between the different clinical dosimetry protocols as Part II of this study. (c) 2005 American Association of Physicists in Medicine.},
  author       = {Binns, P J and Riley, K J and Harling, O K and Kiger, W S and Munck af Rosenschöld, Per and Giusti, V and Capala, J and Skold, K and Auterinen, I and Seren, T and Kotiluoto, P and Uusi-Simola, J and Marek, M and Viererbl, L and Spurny, F},
  issn         = {0094-2405},
  keyword      = {dosimetry intercomparison,BNCT,thermal neutrons},
  language     = {eng},
  number       = {12},
  pages        = {3729--3736},
  publisher    = {American Association of Physicists in Medicine},
  series       = {Medical Physics},
  title        = {An international dosimetry exchange for boron neutron capture therapy, Part I: Absorbed dose measurements},
  url          = {http://dx.doi.org/10.1118/1.2132572},
  volume       = {32},
  year         = {2005},
}