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Osseointegration of a novel injection molded 2-piece ceramic dental implant : a study in minipigs

Thomé, Geninho ; Sandgren, Rebecca LU ; Bernardes, Sergio ; Trojan, Larissa ; Warfving, Nils ; Bellón, Benjamin and Pippenger, Benjamin E. (2021) In Clinical Oral Investigations 25(2). p.603-615
Abstract

Objectives: This study compared the osseointegrative potential of a novel injection molded zirconia dental implant (Neodent Zi ceramic implant, test) and a commercially available titanium implant (Neodent Alvim implant, control) in terms of histomorphometrically derived bone-to-implant contact (BIC), first bone-to-implant contact (fBIC), and the ratio of bone area to total area (BATA) around the implant. Materials and methods: A total of 36 implants, 18 per individual test device, were implanted in a split-mouth arrangement in either side of the edentulous and fully healed mandible of 6 minipigs. Histomorphometric analysis of BIC, fBIC, and BATA were performed 8 weeks post implantation and subjected to statistical non-inferiority... (More)

Objectives: This study compared the osseointegrative potential of a novel injection molded zirconia dental implant (Neodent Zi ceramic implant, test) and a commercially available titanium implant (Neodent Alvim implant, control) in terms of histomorphometrically derived bone-to-implant contact (BIC), first bone-to-implant contact (fBIC), and the ratio of bone area to total area (BATA) around the implant. Materials and methods: A total of 36 implants, 18 per individual test device, were implanted in a split-mouth arrangement in either side of the edentulous and fully healed mandible of 6 minipigs. Histomorphometric analysis of BIC, fBIC, and BATA were performed 8 weeks post implantation and subjected to statistical non-inferiority testing. Surface characteristics of both implant types were compared in terms of contact angle, surface topography, and elemental composition. Results: BIC, fBIC, and coronal BATA values of test and control implants were statistically comparable and non-inferior. BIC values of 77.8 ± 6.9% vs. 80.7 ± 6.9% (p = 0.095) were measured for the test and control groups. fBIC lingual values were − 238 ± 328 μm compared with − 414 ± 511 μm (p = 0.121) while buccal values were − 429 ± 648 μm and − 588 ± 550 μm (p = 0.230) for the test and control devices, respectively. BATA in the apical segment was significantly higher in the test group compared with the control group (67.2 ± 11.8% vs. 59.1 ± 11.4%) (p = 0.0103). Surface topographies of both implant types were comparable. Surface chemical analysis indicated the presence of carbonaceous adsorbates which correlated with a comparable and predominantly hydrophobic character of the implants. Conclusion: The results demonstrate that the investigated zirconia implants, when compared with a commercially available titanium implant, show equivalent and non-inferior bone integration, bone formation, and alveolar bone level maintenance. This qualifies the investigated zirconia implant as a potential candidate for clinical development. Clinical relevance: This study investigated the osseointegration of a novel zirconia 2-piece dental implant prototype intended for clinical development. With the aim of translating this prototype into clinical development preclinical models, procedures and materials within this study have been selected as close to clinical practice and human physiological conditions as possible.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ceramic, Dental implant, In vivo, Injection molding, Osseointegration
in
Clinical Oral Investigations
volume
25
issue
2
pages
603 - 615
publisher
Springer
external identifiers
  • pmid:32914271
  • scopus:85090782555
ISSN
1432-6981
DOI
10.1007/s00784-020-03513-z
language
English
LU publication?
yes
id
20c528de-79e9-46e4-bd89-4f184d50b141
date added to LUP
2020-10-20 11:18:13
date last changed
2021-06-16 04:47:47
@article{20c528de-79e9-46e4-bd89-4f184d50b141,
  abstract     = {<p>Objectives: This study compared the osseointegrative potential of a novel injection molded zirconia dental implant (Neodent Zi ceramic implant, test) and a commercially available titanium implant (Neodent Alvim implant, control) in terms of histomorphometrically derived bone-to-implant contact (BIC), first bone-to-implant contact (fBIC), and the ratio of bone area to total area (BATA) around the implant. Materials and methods: A total of 36 implants, 18 per individual test device, were implanted in a split-mouth arrangement in either side of the edentulous and fully healed mandible of 6 minipigs. Histomorphometric analysis of BIC, fBIC, and BATA were performed 8 weeks post implantation and subjected to statistical non-inferiority testing. Surface characteristics of both implant types were compared in terms of contact angle, surface topography, and elemental composition. Results: BIC, fBIC, and coronal BATA values of test and control implants were statistically comparable and non-inferior. BIC values of 77.8 ± 6.9% vs. 80.7 ± 6.9% (p = 0.095) were measured for the test and control groups. fBIC lingual values were − 238 ± 328 μm compared with − 414 ± 511 μm (p = 0.121) while buccal values were − 429 ± 648 μm and − 588 ± 550 μm (p = 0.230) for the test and control devices, respectively. BATA in the apical segment was significantly higher in the test group compared with the control group (67.2 ± 11.8% vs. 59.1 ± 11.4%) (p = 0.0103). Surface topographies of both implant types were comparable. Surface chemical analysis indicated the presence of carbonaceous adsorbates which correlated with a comparable and predominantly hydrophobic character of the implants. Conclusion: The results demonstrate that the investigated zirconia implants, when compared with a commercially available titanium implant, show equivalent and non-inferior bone integration, bone formation, and alveolar bone level maintenance. This qualifies the investigated zirconia implant as a potential candidate for clinical development. Clinical relevance: This study investigated the osseointegration of a novel zirconia 2-piece dental implant prototype intended for clinical development. With the aim of translating this prototype into clinical development preclinical models, procedures and materials within this study have been selected as close to clinical practice and human physiological conditions as possible.</p>},
  author       = {Thomé, Geninho and Sandgren, Rebecca and Bernardes, Sergio and Trojan, Larissa and Warfving, Nils and Bellón, Benjamin and Pippenger, Benjamin E.},
  issn         = {1432-6981},
  language     = {eng},
  number       = {2},
  pages        = {603--615},
  publisher    = {Springer},
  series       = {Clinical Oral Investigations},
  title        = {Osseointegration of a novel injection molded 2-piece ceramic dental implant : a study in minipigs},
  url          = {http://dx.doi.org/10.1007/s00784-020-03513-z},
  doi          = {10.1007/s00784-020-03513-z},
  volume       = {25},
  year         = {2021},
}