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Locus-specific introgression in young hybrid swarms : Drift may dominate selection

McFarlane, S. Eryn LU ; Senn, Helen V. ; Smith, Stephanie L. and Pemberton, Josephine M. (2021) In Molecular Ecology 30(9). p.2104-2115
Abstract

Closely related species that have previously inhabited geographically separated ranges are hybridizing at an increasing rate due to human disruptions. These human-mediated hybrid zones can be used to study reproductive isolation between species at secondary contact, including examining locus-specific rates of introgression. Introgression is expected to be heterogenous across the genome, reflecting variation in selection. Those loci that introgress especially slowly are good candidates for being involved in reproductive isolation, while those loci that introgress quickly may be involved in adaptive introgression. In the context of conservation, policy makers are especially concerned about introduced alleles moving quickly into the... (More)

Closely related species that have previously inhabited geographically separated ranges are hybridizing at an increasing rate due to human disruptions. These human-mediated hybrid zones can be used to study reproductive isolation between species at secondary contact, including examining locus-specific rates of introgression. Introgression is expected to be heterogenous across the genome, reflecting variation in selection. Those loci that introgress especially slowly are good candidates for being involved in reproductive isolation, while those loci that introgress quickly may be involved in adaptive introgression. In the context of conservation, policy makers are especially concerned about introduced alleles moving quickly into the background of a native or endemic species, as these alleles could replace the native alleles in the population, leading to extinction via hybridization. We applied genomic cline analyses to 44,997 SNPs to identify loci introgressing more or less when compared to the genome wide expectation in a human-mediated hybridizing population of red deer and sika in Kintyre Scotland. We found 11.4% of SNPs had cline centres that were significantly different from the genome wide expectation, and 17.6% of all SNPs had excess rates of introgression. Based on simulations, we believe that many of these markers have diverged from the genome-wide average due to drift, rather than because of selection, and we suggest that these simulations can be useful as a null distribution for future studies of genomic clines. Future work on red deer and sika could determine the policy implications of allelic-replacement due to drift rather than selection, and could use replicate, geographically distinct hybrid zones to narrow down those loci that are responding to selection.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anthropogenic hybridization, C. Nippon, Cervus elaphus, genomic cline, introgression
in
Molecular Ecology
volume
30
issue
9
pages
12 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85102236249
  • pmid:33638185
ISSN
0962-1083
DOI
10.1111/mec.15862
language
English
LU publication?
yes
id
20daa493-b784-494d-b91e-dbf7c5e94151
date added to LUP
2021-03-29 12:36:10
date last changed
2024-06-15 08:43:20
@article{20daa493-b784-494d-b91e-dbf7c5e94151,
  abstract     = {{<p>Closely related species that have previously inhabited geographically separated ranges are hybridizing at an increasing rate due to human disruptions. These human-mediated hybrid zones can be used to study reproductive isolation between species at secondary contact, including examining locus-specific rates of introgression. Introgression is expected to be heterogenous across the genome, reflecting variation in selection. Those loci that introgress especially slowly are good candidates for being involved in reproductive isolation, while those loci that introgress quickly may be involved in adaptive introgression. In the context of conservation, policy makers are especially concerned about introduced alleles moving quickly into the background of a native or endemic species, as these alleles could replace the native alleles in the population, leading to extinction via hybridization. We applied genomic cline analyses to 44,997 SNPs to identify loci introgressing more or less when compared to the genome wide expectation in a human-mediated hybridizing population of red deer and sika in Kintyre Scotland. We found 11.4% of SNPs had cline centres that were significantly different from the genome wide expectation, and 17.6% of all SNPs had excess rates of introgression. Based on simulations, we believe that many of these markers have diverged from the genome-wide average due to drift, rather than because of selection, and we suggest that these simulations can be useful as a null distribution for future studies of genomic clines. Future work on red deer and sika could determine the policy implications of allelic-replacement due to drift rather than selection, and could use replicate, geographically distinct hybrid zones to narrow down those loci that are responding to selection.</p>}},
  author       = {{McFarlane, S. Eryn and Senn, Helen V. and Smith, Stephanie L. and Pemberton, Josephine M.}},
  issn         = {{0962-1083}},
  keywords     = {{anthropogenic hybridization; C. Nippon; Cervus elaphus; genomic cline; introgression}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{9}},
  pages        = {{2104--2115}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Molecular Ecology}},
  title        = {{Locus-specific introgression in young hybrid swarms : Drift may dominate selection}},
  url          = {{http://dx.doi.org/10.1111/mec.15862}},
  doi          = {{10.1111/mec.15862}},
  volume       = {{30}},
  year         = {{2021}},
}