Lung function after extremely preterm birth-A population-based cohort study (EXPRESS)
(2018) In Pediatric Pulmonology 53(1). p.64-72- Abstract
BACKGROUND AND OBJECTIVES: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation).
METHODS: In a population-based cohort of children born extremely preterm and controls born at term (n = 350), follow-up at 6½-years-of-age was performed using spirometry and impulse oscillometry. Associations to gestational age, smallness for gestational age (SGA), and bronchopulmonary dysplasia (BPD) were assessed.
RESULTS: Children born extremely preterm had lower forced vital capacity (FVC,... (More)
BACKGROUND AND OBJECTIVES: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation).
METHODS: In a population-based cohort of children born extremely preterm and controls born at term (n = 350), follow-up at 6½-years-of-age was performed using spirometry and impulse oscillometry. Associations to gestational age, smallness for gestational age (SGA), and bronchopulmonary dysplasia (BPD) were assessed.
RESULTS: Children born extremely preterm had lower forced vital capacity (FVC, z-score: -0.7, 95%CI: -1.0;-0.4), forced expiratory volume (FEV1 , z-score: -1.1, 95%CI: -1.4; -0.8), higher frequency-dependence of resistance (R5-20 , 0.09, 95%CI: 0.05; 0.12 kPa · L-1 · s-1 ) and larger area under the reactance curve (AX, 0.78, 95%CI: 0.49; 1.07 kPa · L-1 ) than controls. In children born at 22-24 weeks of gestation, 24% had FVC and 44% had FEV1 below the lower limit of normal. SGA and severe BPD only marginally contributed to pulmonary outcomes. Asthma-like disease was reported in 40% of extremely preterm children and 15% of controls.
CONCLUSION: Many children born extremely preterm have altered airway mechanics and significant obstructive reduction in lung function. This warrants consideration for treatment and continued follow-up.
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- author
- Thunqvist, Per ; Tufvesson, Ellen LU ; Bjermer, Leif LU ; Winberg, Anna ; Fellman, Vineta LU ; Domellöf, Magnus ; Melén, Erik ; Norman, Mikael and Hallberg, Jenny
- organization
- publishing date
- 2018-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Asthma/physiopathology, Bronchopulmonary Dysplasia/physiopathology, Child, Cohort Studies, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Infant, Extremely Premature/physiology, Infant, Newborn, Lung/physiopathology, Male, Premature Birth/physiopathology, Respiratory Function Tests, Spirometry, Vital Capacity
- in
- Pediatric Pulmonology
- volume
- 53
- issue
- 1
- pages
- 64 - 72
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85034238979
- pmid:29152899
- ISSN
- 8755-6863
- DOI
- 10.1002/ppul.23919
- language
- English
- LU publication?
- yes
- additional info
- © 2017 Wiley Periodicals, Inc.
- id
- 20db9d64-d425-466f-b79e-00a9ccc68c66
- date added to LUP
- 2019-07-01 08:54:25
- date last changed
- 2024-09-05 03:38:45
@article{20db9d64-d425-466f-b79e-00a9ccc68c66, abstract = {{<p>BACKGROUND AND OBJECTIVES: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation).</p><p>METHODS: In a population-based cohort of children born extremely preterm and controls born at term (n = 350), follow-up at 6½-years-of-age was performed using spirometry and impulse oscillometry. Associations to gestational age, smallness for gestational age (SGA), and bronchopulmonary dysplasia (BPD) were assessed.</p><p>RESULTS: Children born extremely preterm had lower forced vital capacity (FVC, z-score: -0.7, 95%CI: -1.0;-0.4), forced expiratory volume (FEV1 , z-score: -1.1, 95%CI: -1.4; -0.8), higher frequency-dependence of resistance (R5-20 , 0.09, 95%CI: 0.05; 0.12 kPa · L-1 · s-1 ) and larger area under the reactance curve (AX, 0.78, 95%CI: 0.49; 1.07 kPa · L-1 ) than controls. In children born at 22-24 weeks of gestation, 24% had FVC and 44% had FEV1 below the lower limit of normal. SGA and severe BPD only marginally contributed to pulmonary outcomes. Asthma-like disease was reported in 40% of extremely preterm children and 15% of controls.</p><p>CONCLUSION: Many children born extremely preterm have altered airway mechanics and significant obstructive reduction in lung function. This warrants consideration for treatment and continued follow-up.</p>}}, author = {{Thunqvist, Per and Tufvesson, Ellen and Bjermer, Leif and Winberg, Anna and Fellman, Vineta and Domellöf, Magnus and Melén, Erik and Norman, Mikael and Hallberg, Jenny}}, issn = {{8755-6863}}, keywords = {{Asthma/physiopathology; Bronchopulmonary Dysplasia/physiopathology; Child; Cohort Studies; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Infant, Extremely Premature/physiology; Infant, Newborn; Lung/physiopathology; Male; Premature Birth/physiopathology; Respiratory Function Tests; Spirometry; Vital Capacity}}, language = {{eng}}, number = {{1}}, pages = {{64--72}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Pediatric Pulmonology}}, title = {{Lung function after extremely preterm birth-A population-based cohort study (EXPRESS)}}, url = {{http://dx.doi.org/10.1002/ppul.23919}}, doi = {{10.1002/ppul.23919}}, volume = {{53}}, year = {{2018}}, }