Enantioselective synthesis of : Anti -3-alkenyl-2-amido-3-hydroxy esters: Application to the total synthesis of (+)-alexine
(2019) In RSC Advances 9(5). p.2799-2802- Abstract
A straightforward synthesis of anti-3-alkenyl-2-amido-3-hydroxy esters from the corresponding racemic α-amino-β-keto esters by using a ATH/DKR protocol has been developed. This method gives moderate to excellent yields with high chemo-, diastereo- and enantioselectivities for a broad range of substrates. In order to highlight the versatility of the methodology it was applied in an efficient asymmetric synthesis of the polyhydroxylated pyrrolizidine alkaloid (+)-alexine.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/20e9c07f-3e64-46bd-9c34-a5728d15a3f7
- author
- Yu, Lu LU and Somfai, Peter LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- RSC Advances
- volume
- 9
- issue
- 5
- pages
- 4 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:85060607661
- ISSN
- 2046-2069
- DOI
- 10.1039/c9ra00173e
- language
- English
- LU publication?
- yes
- id
- 20e9c07f-3e64-46bd-9c34-a5728d15a3f7
- date added to LUP
- 2019-02-06 14:42:49
- date last changed
- 2022-04-25 21:00:02
@article{20e9c07f-3e64-46bd-9c34-a5728d15a3f7, abstract = {{<p>A straightforward synthesis of anti-3-alkenyl-2-amido-3-hydroxy esters from the corresponding racemic α-amino-β-keto esters by using a ATH/DKR protocol has been developed. This method gives moderate to excellent yields with high chemo-, diastereo- and enantioselectivities for a broad range of substrates. In order to highlight the versatility of the methodology it was applied in an efficient asymmetric synthesis of the polyhydroxylated pyrrolizidine alkaloid (+)-alexine.</p>}}, author = {{Yu, Lu and Somfai, Peter}}, issn = {{2046-2069}}, language = {{eng}}, number = {{5}}, pages = {{2799--2802}}, publisher = {{Royal Society of Chemistry}}, series = {{RSC Advances}}, title = {{Enantioselective synthesis of : Anti -3-alkenyl-2-amido-3-hydroxy esters: Application to the total synthesis of (+)-alexine}}, url = {{http://dx.doi.org/10.1039/c9ra00173e}}, doi = {{10.1039/c9ra00173e}}, volume = {{9}}, year = {{2019}}, }