Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease
(2014) In Annals of the Rheumatic Diseases 73(8). p.4-1541- Abstract
OBJECTIVES: Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA).
METHODS: We used the cases from the population-based EIRA study (N=617), followed in the Swedish Rheumatology Quality Register, calculating the odds of having above median level of 28-joint disease activity score (DAS28), physician assessment, pain (visual-analogue scale (VAS), VAS-pain) and activity limitation (health assessment questionnaire (HAQ)) at diagnosis, as an effect of physical activity 5 years before diagnosis, investigated both in categories and dichotomised.
RESULTS: Dose-response relationships were seen for all measures; the higher the level of... (More)
OBJECTIVES: Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA).
METHODS: We used the cases from the population-based EIRA study (N=617), followed in the Swedish Rheumatology Quality Register, calculating the odds of having above median level of 28-joint disease activity score (DAS28), physician assessment, pain (visual-analogue scale (VAS), VAS-pain) and activity limitation (health assessment questionnaire (HAQ)) at diagnosis, as an effect of physical activity 5 years before diagnosis, investigated both in categories and dichotomised.
RESULTS: Dose-response relationships were seen for all measures; the higher the level of physical activity, the lower the likelihood of having outcome measure above median. Further, regular physical activity associated with 42% reduced odds of having DAS28 above median (OR=0.58 (95% CI 0.42 to 0.81)). Effects were similar for VAS-pain (OR=0.62 (95%CI 0.45 to 0.86)) and physician assessment (OR=0.67 (95%CI 0.47 to 0.95)) but not for HAQ. Statistically significant effects were also found both for the combined objective components and the combined subjective components of DAS28.
CONCLUSIONS: Physically active individuals seem to present with milder RA, which adds to the evidence of beneficial effects of physical activity on inflammatory diseases. The observation should be important for both health professionals and individuals seeking to reduce their risk.
(Less)
- author
- Sandberg, Maria E C LU ; Wedrén, Sara ; Klareskog, Lars ; Lundberg, Ingrid E. ; Opava, Christina H ; Alfredsson, Lars and Saevarsdottir, Saedis
- publishing date
- 2014-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Aged, Arthralgia, Arthritis, Rheumatoid, Female, Health Surveys, Humans, Logistic Models, Male, Middle Aged, Motor Activity, Pain Measurement, Registries, Risk Factors, Severity of Illness Index, Surveys and Questionnaires, Journal Article, Research Support, Non-U.S. Gov't
- in
- Annals of the Rheumatic Diseases
- volume
- 73
- issue
- 8
- pages
- 4 pages
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:84903882472
- pmid:24641943
- ISSN
- 1468-2060
- DOI
- 10.1136/annrheumdis-2014-205180
- language
- English
- LU publication?
- no
- id
- 20fe7c68-c1d1-4c65-ab83-888b60fa7815
- date added to LUP
- 2017-10-16 08:58:06
- date last changed
- 2024-01-14 07:32:32
@article{20fe7c68-c1d1-4c65-ab83-888b60fa7815,
abstract = {{<p>OBJECTIVES: Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA).</p><p>METHODS: We used the cases from the population-based EIRA study (N=617), followed in the Swedish Rheumatology Quality Register, calculating the odds of having above median level of 28-joint disease activity score (DAS28), physician assessment, pain (visual-analogue scale (VAS), VAS-pain) and activity limitation (health assessment questionnaire (HAQ)) at diagnosis, as an effect of physical activity 5 years before diagnosis, investigated both in categories and dichotomised.</p><p>RESULTS: Dose-response relationships were seen for all measures; the higher the level of physical activity, the lower the likelihood of having outcome measure above median. Further, regular physical activity associated with 42% reduced odds of having DAS28 above median (OR=0.58 (95% CI 0.42 to 0.81)). Effects were similar for VAS-pain (OR=0.62 (95%CI 0.45 to 0.86)) and physician assessment (OR=0.67 (95%CI 0.47 to 0.95)) but not for HAQ. Statistically significant effects were also found both for the combined objective components and the combined subjective components of DAS28.</p><p>CONCLUSIONS: Physically active individuals seem to present with milder RA, which adds to the evidence of beneficial effects of physical activity on inflammatory diseases. The observation should be important for both health professionals and individuals seeking to reduce their risk.</p>}},
author = {{Sandberg, Maria E C and Wedrén, Sara and Klareskog, Lars and Lundberg, Ingrid E. and Opava, Christina H and Alfredsson, Lars and Saevarsdottir, Saedis}},
issn = {{1468-2060}},
keywords = {{Adult; Aged; Arthralgia; Arthritis, Rheumatoid; Female; Health Surveys; Humans; Logistic Models; Male; Middle Aged; Motor Activity; Pain Measurement; Registries; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{8}},
pages = {{4--1541}},
publisher = {{BMJ Publishing Group}},
series = {{Annals of the Rheumatic Diseases}},
title = {{Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease}},
url = {{http://dx.doi.org/10.1136/annrheumdis-2014-205180}},
doi = {{10.1136/annrheumdis-2014-205180}},
volume = {{73}},
year = {{2014}},
}