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Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease

Sandberg, Maria E C LU ; Wedrén, Sara; Klareskog, Lars; Lundberg, Ingrid E.; Opava, Christina H; Alfredsson, Lars and Saevarsdottir, Saedis (2014) In Annals of the Rheumatic Diseases 73(8). p.4-1541
Abstract

OBJECTIVES: Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA).

METHODS: We used the cases from the population-based EIRA study (N=617), followed in the Swedish Rheumatology Quality Register, calculating the odds of having above median level of 28-joint disease activity score (DAS28), physician assessment, pain (visual-analogue scale (VAS), VAS-pain) and activity limitation (health assessment questionnaire (HAQ)) at diagnosis, as an effect of physical activity 5 years before diagnosis, investigated both in categories and dichotomised.

RESULTS: Dose-response relationships were seen for all measures; the higher the level of... (More)

OBJECTIVES: Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA).

METHODS: We used the cases from the population-based EIRA study (N=617), followed in the Swedish Rheumatology Quality Register, calculating the odds of having above median level of 28-joint disease activity score (DAS28), physician assessment, pain (visual-analogue scale (VAS), VAS-pain) and activity limitation (health assessment questionnaire (HAQ)) at diagnosis, as an effect of physical activity 5 years before diagnosis, investigated both in categories and dichotomised.

RESULTS: Dose-response relationships were seen for all measures; the higher the level of physical activity, the lower the likelihood of having outcome measure above median. Further, regular physical activity associated with 42% reduced odds of having DAS28 above median (OR=0.58 (95% CI 0.42 to 0.81)). Effects were similar for VAS-pain (OR=0.62 (95%CI 0.45 to 0.86)) and physician assessment (OR=0.67 (95%CI 0.47 to 0.95)) but not for HAQ. Statistically significant effects were also found both for the combined objective components and the combined subjective components of DAS28.

CONCLUSIONS: Physically active individuals seem to present with milder RA, which adds to the evidence of beneficial effects of physical activity on inflammatory diseases. The observation should be important for both health professionals and individuals seeking to reduce their risk.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Aged, Arthralgia, Arthritis, Rheumatoid, Female, Health Surveys, Humans, Logistic Models, Male, Middle Aged, Motor Activity, Pain Measurement, Registries, Risk Factors, Severity of Illness Index, Surveys and Questionnaires, Journal Article, Research Support, Non-U.S. Gov't
in
Annals of the Rheumatic Diseases
volume
73
issue
8
pages
4 pages
publisher
British Medical Association
external identifiers
  • scopus:84903882472
ISSN
1468-2060
DOI
10.1136/annrheumdis-2014-205180
language
English
LU publication?
no
id
20fe7c68-c1d1-4c65-ab83-888b60fa7815
date added to LUP
2017-10-16 08:58:06
date last changed
2017-10-22 05:37:01
@article{20fe7c68-c1d1-4c65-ab83-888b60fa7815,
  abstract     = {<p>OBJECTIVES: Physical activity has been shown to decrease inflammatory markers; here we investigate the effect on the clinical presentation of rheumatoid arthritis (RA).</p><p>METHODS: We used the cases from the population-based EIRA study (N=617), followed in the Swedish Rheumatology Quality Register, calculating the odds of having above median level of 28-joint disease activity score (DAS28), physician assessment, pain (visual-analogue scale (VAS), VAS-pain) and activity limitation (health assessment questionnaire (HAQ)) at diagnosis, as an effect of physical activity 5 years before diagnosis, investigated both in categories and dichotomised.</p><p>RESULTS: Dose-response relationships were seen for all measures; the higher the level of physical activity, the lower the likelihood of having outcome measure above median. Further, regular physical activity associated with 42% reduced odds of having DAS28 above median (OR=0.58 (95% CI 0.42 to 0.81)). Effects were similar for VAS-pain (OR=0.62 (95%CI 0.45 to 0.86)) and physician assessment (OR=0.67 (95%CI 0.47 to 0.95)) but not for HAQ. Statistically significant effects were also found both for the combined objective components and the combined subjective components of DAS28.</p><p>CONCLUSIONS: Physically active individuals seem to present with milder RA, which adds to the evidence of beneficial effects of physical activity on inflammatory diseases. The observation should be important for both health professionals and individuals seeking to reduce their risk.</p>},
  author       = {Sandberg, Maria E C and Wedrén, Sara and Klareskog, Lars and Lundberg, Ingrid E. and Opava, Christina H and Alfredsson, Lars and Saevarsdottir, Saedis},
  issn         = {1468-2060},
  keyword      = {Adult,Aged,Arthralgia,Arthritis, Rheumatoid,Female,Health Surveys,Humans,Logistic Models,Male,Middle Aged,Motor Activity,Pain Measurement,Registries,Risk Factors,Severity of Illness Index,Surveys and Questionnaires,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {8},
  pages        = {4--1541},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2014-205180},
  volume       = {73},
  year         = {2014},
}