Stretch-dependent growth and differentiation in vascular smooth muscle: role of the actin cytoskeleton
(2005) In Canadian Journal of Physiology and Pharmacology 83(10). p.869-875- Abstract
- The smooth muscle cells in the vascular wall are constantly exposed to distending forces from the intraluminal pressure. A rise in blood pressure triggers growth of the vessel wall, which is characterized primarily by hypertrophy of smooth muscle cells with maintained differentiation in a contractile phenotype. Growth factor stimulation of dissociated smooth muscle cells, on the other hand, causes proliferative growth with loss of contractility. This type of response is also found in neointima development following angioplasty and in atherosclerotic lesions. An intact tissue environment is therefore critical for preserved differentiation. Recent advances point to a role of actin polymerization in the expression of smooth muscle... (More)
- The smooth muscle cells in the vascular wall are constantly exposed to distending forces from the intraluminal pressure. A rise in blood pressure triggers growth of the vessel wall, which is characterized primarily by hypertrophy of smooth muscle cells with maintained differentiation in a contractile phenotype. Growth factor stimulation of dissociated smooth muscle cells, on the other hand, causes proliferative growth with loss of contractility. This type of response is also found in neointima development following angioplasty and in atherosclerotic lesions. An intact tissue environment is therefore critical for preserved differentiation. Recent advances point to a role of actin polymerization in the expression of smooth muscle differentiation marker genes, in concert with serum response factor (SRF) and cofactors, such as myocardin. Stretch of intact venous smooth muscle activates Rho and inhibits the actin filament severing factor cofilin, resulting in increased actin polymerization. Concomitantly, the rates of synthesis of SRF-regulated differentiation markers, such as SM22 alpha, calponin, and alpha-actin, are increased. This increase in differentiation signals is parallel with activation of the mitogen-activated protein (MAP) kinase pathway. Thus stretch-induced growth in a maintained contractile phenotype occurs by dual activation of signal pathways regulating both growth and differentiation. A current challenge is to identify sites of crosstalk between these pathways in intact smooth muscle tissue. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/210314
- author
- Hellstrand, Per LU and Albinsson, Sebastian LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ERK, stretch, hypertension, caveolae, Rho
- in
- Canadian Journal of Physiology and Pharmacology
- volume
- 83
- issue
- 10
- pages
- 869 - 875
- publisher
- National Research Council Canada
- external identifiers
-
- wos:000234416100010
- pmid:16333359
- scopus:32544456762
- pmid:16333359
- ISSN
- 0008-4212
- DOI
- 10.1139/y05-061
- language
- English
- LU publication?
- yes
- id
- 8239fa89-d876-4d08-9828-a49909cb914c (old id 210314)
- date added to LUP
- 2016-04-01 11:50:42
- date last changed
- 2022-04-28 20:50:18
@article{8239fa89-d876-4d08-9828-a49909cb914c,
abstract = {{The smooth muscle cells in the vascular wall are constantly exposed to distending forces from the intraluminal pressure. A rise in blood pressure triggers growth of the vessel wall, which is characterized primarily by hypertrophy of smooth muscle cells with maintained differentiation in a contractile phenotype. Growth factor stimulation of dissociated smooth muscle cells, on the other hand, causes proliferative growth with loss of contractility. This type of response is also found in neointima development following angioplasty and in atherosclerotic lesions. An intact tissue environment is therefore critical for preserved differentiation. Recent advances point to a role of actin polymerization in the expression of smooth muscle differentiation marker genes, in concert with serum response factor (SRF) and cofactors, such as myocardin. Stretch of intact venous smooth muscle activates Rho and inhibits the actin filament severing factor cofilin, resulting in increased actin polymerization. Concomitantly, the rates of synthesis of SRF-regulated differentiation markers, such as SM22 alpha, calponin, and alpha-actin, are increased. This increase in differentiation signals is parallel with activation of the mitogen-activated protein (MAP) kinase pathway. Thus stretch-induced growth in a maintained contractile phenotype occurs by dual activation of signal pathways regulating both growth and differentiation. A current challenge is to identify sites of crosstalk between these pathways in intact smooth muscle tissue.}},
author = {{Hellstrand, Per and Albinsson, Sebastian}},
issn = {{0008-4212}},
keywords = {{ERK; stretch; hypertension; caveolae; Rho}},
language = {{eng}},
number = {{10}},
pages = {{869--875}},
publisher = {{National Research Council Canada}},
series = {{Canadian Journal of Physiology and Pharmacology}},
title = {{Stretch-dependent growth and differentiation in vascular smooth muscle: role of the actin cytoskeleton}},
url = {{http://dx.doi.org/10.1139/y05-061}},
doi = {{10.1139/y05-061}},
volume = {{83}},
year = {{2005}},
}