Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology
(2005) In Journal of Computational and Theoretical Nanoscience 2(3). p.389-395- Abstract
- Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. Bymeasuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/210fb12e-1f71-4976-9f2a-457aa9d45164
- author
- Metzler, Ralf and Ambjörnsson, Tobias LU
- publishing date
- 2005-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Computational and Theoretical Nanoscience
- volume
- 2
- issue
- 3
- pages
- 389 - 395
- publisher
- American Scientific Publishers
- external identifiers
-
- scopus:27644509796
- ISSN
- 1546-1955
- DOI
- 10.1166/jctn.2005.209
- language
- English
- LU publication?
- no
- id
- 210fb12e-1f71-4976-9f2a-457aa9d45164
- alternative location
- http://www.ingentaselect.com/rpsv/cgi-bin/cgi?ini=xref&body=linker&reqdoi=10.1166/jctn.2005.209
- date added to LUP
- 2019-05-03 11:45:04
- date last changed
- 2022-03-31 17:21:29
@article{210fb12e-1f71-4976-9f2a-457aa9d45164,
abstract = {{Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. Bymeasuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.}},
author = {{Metzler, Ralf and Ambjörnsson, Tobias}},
issn = {{1546-1955}},
language = {{eng}},
month = {{09}},
number = {{3}},
pages = {{389--395}},
publisher = {{American Scientific Publishers}},
series = {{Journal of Computational and Theoretical Nanoscience}},
title = {{Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology}},
url = {{http://dx.doi.org/10.1166/jctn.2005.209}},
doi = {{10.1166/jctn.2005.209}},
volume = {{2}},
year = {{2005}},
}