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Strength at the extracellular matrix-muscle interface

Grounds, MD; Sorokin, Lydia LU and White, J (2005) In Scandinavian Journal of Medicine & Science in Sports 15(6). p.381-391
Abstract
Mechanical force is generated within skeletal muscle cells by contraction of specialized myofibrillar proteins. This paper explores how the contractile force generated at the sarcomeres within an individual muscle fiber is transferred through the connective tissue to move the bones. The initial key point for transfer of the contractile force is the muscle cell membrane (sarcolemma) where force is transferred laterally to the basement membrane (specialized extracellular matrix rich in laminins) to be integrated within the connective tissue (rich in collagens) before transmission to the tendons. Connections between (1) key molecules outside the myofiber in the basement membrane to (2) molecules within the sarcolemma of the myofiber and (3)... (More)
Mechanical force is generated within skeletal muscle cells by contraction of specialized myofibrillar proteins. This paper explores how the contractile force generated at the sarcomeres within an individual muscle fiber is transferred through the connective tissue to move the bones. The initial key point for transfer of the contractile force is the muscle cell membrane (sarcolemma) where force is transferred laterally to the basement membrane (specialized extracellular matrix rich in laminins) to be integrated within the connective tissue (rich in collagens) before transmission to the tendons. Connections between (1) key molecules outside the myofiber in the basement membrane to (2) molecules within the sarcolemma of the myofiber and (3) the internal cytoplasmic structures of the cytoskeleton and sarcomeres are evaluated. Disturbances to many components of this complex interactive system adversely affect skeletal muscle strength and integrity, and can result in severe muscle diseases. The mechanical aspects of these crucial linkages are discussed, with particular reference to defects in laminin-alpha 2 and integrin-alpha 7. Novel interventions to potentially increase muscle strength and reduce myofiber damage are mentioned, and these are also highly relevant to muscle diseases and aging muscle. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
skeletal muscle, myofiber strength, integrins, laminins, basement membrane, sarcolemma, exercise, muscle damage
in
Scandinavian Journal of Medicine & Science in Sports
volume
15
issue
6
pages
381 - 391
publisher
Wiley-Blackwell
external identifiers
  • pmid:16293150
  • wos:000233284200003
  • scopus:28644439538
ISSN
1600-0838
DOI
10.1111/j.1600-0838.2005.00467.x
language
English
LU publication?
yes
id
60b95b40-313a-4a20-affe-66b217293db0 (old id 212493)
date added to LUP
2007-08-24 13:34:53
date last changed
2017-11-05 04:39:47
@article{60b95b40-313a-4a20-affe-66b217293db0,
  abstract     = {Mechanical force is generated within skeletal muscle cells by contraction of specialized myofibrillar proteins. This paper explores how the contractile force generated at the sarcomeres within an individual muscle fiber is transferred through the connective tissue to move the bones. The initial key point for transfer of the contractile force is the muscle cell membrane (sarcolemma) where force is transferred laterally to the basement membrane (specialized extracellular matrix rich in laminins) to be integrated within the connective tissue (rich in collagens) before transmission to the tendons. Connections between (1) key molecules outside the myofiber in the basement membrane to (2) molecules within the sarcolemma of the myofiber and (3) the internal cytoplasmic structures of the cytoskeleton and sarcomeres are evaluated. Disturbances to many components of this complex interactive system adversely affect skeletal muscle strength and integrity, and can result in severe muscle diseases. The mechanical aspects of these crucial linkages are discussed, with particular reference to defects in laminin-alpha 2 and integrin-alpha 7. Novel interventions to potentially increase muscle strength and reduce myofiber damage are mentioned, and these are also highly relevant to muscle diseases and aging muscle.},
  author       = {Grounds, MD and Sorokin, Lydia and White, J},
  issn         = {1600-0838},
  keyword      = {skeletal muscle,myofiber strength,integrins,laminins,basement membrane,sarcolemma,exercise,muscle damage},
  language     = {eng},
  number       = {6},
  pages        = {381--391},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Medicine & Science in Sports},
  title        = {Strength at the extracellular matrix-muscle interface},
  url          = {http://dx.doi.org/10.1111/j.1600-0838.2005.00467.x},
  volume       = {15},
  year         = {2005},
}