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Lateral pressure profiles in cholesterol-DPPC bilayers

Patra, Michael LU (2005) In European Biophysics Journal 35(1). p.79-88
Abstract
By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between... (More)
By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between cholesterol and molecules such as membrane proteins mediated solely via the lateral pressure profile might become possible. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ion channel regulation, lipid bilayer, energetics, thermodynamics
in
European Biophysics Journal
volume
35
issue
1
pages
79 - 88
publisher
Springer
external identifiers
  • wos:000233392200007
  • pmid:16205919
  • scopus:27944504707
ISSN
0175-7571
DOI
10.1007/s00249-005-0011-0
language
English
LU publication?
yes
id
c0cc0112-ed5e-457f-852d-a97bc4d22871 (old id 213226)
date added to LUP
2007-08-16 15:46:42
date last changed
2017-11-05 04:22:30
@article{c0cc0112-ed5e-457f-852d-a97bc4d22871,
  abstract     = {By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between cholesterol and molecules such as membrane proteins mediated solely via the lateral pressure profile might become possible.},
  author       = {Patra, Michael},
  issn         = {0175-7571},
  keyword      = {ion channel regulation,lipid bilayer,energetics,thermodynamics},
  language     = {eng},
  number       = {1},
  pages        = {79--88},
  publisher    = {Springer},
  series       = {European Biophysics Journal},
  title        = {Lateral pressure profiles in cholesterol-DPPC bilayers},
  url          = {http://dx.doi.org/10.1007/s00249-005-0011-0},
  volume       = {35},
  year         = {2005},
}