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Coronary heart disease mortality after 5 years of adjuvant tamoxifen therapy: Results from a randomized trial

Nordenskjold, B; Rosell, J; Rutqvist, L E; Malmström, Per LU ; Bergh, J; Bengtsson, N O; Hatschek, T; Wallgren, A and Carstensen, J (2005) In Journal of the National Cancer Institute 97(21). p.1609-1610
Abstract
From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years of adjuvant tamoxifen therapy with that in patients receiving 5 years of adjuvant tamoxifen therapy, 4175 of whom were recurrence free after 2 years of tamoxifen therapy. Among the 2046 patients randomly assigned to the 5-year group all-cause mortality, breast cancer-specific mortality, and the incidence of contralateral breast cancer were reduced, compared with those among 2129 patients randomized in the 2-year group, but the incidence of endometrial cancer was increased. In addition, mortality from coronary heart disease was statistically significantly reduced in the 5-year group,... (More)
From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years of adjuvant tamoxifen therapy with that in patients receiving 5 years of adjuvant tamoxifen therapy, 4175 of whom were recurrence free after 2 years of tamoxifen therapy. Among the 2046 patients randomly assigned to the 5-year group all-cause mortality, breast cancer-specific mortality, and the incidence of contralateral breast cancer were reduced, compared with those among 2129 patients randomized in the 2-year group, but the incidence of endometrial cancer was increased. In addition, mortality from coronary heart disease was statistically significantly reduced in the 5-year group, compared with that in the 2-year group (hazard ratio = 0.67, 95% confidence interval = 0.47 to 0.94; P = .022 [two-sided Wald test]). Ten years after surgery, 2.1% of the patients in the 5-year group and 3.5% of those in the 2-year group a died from coronary heart disease. No statistically significant increases in mortality from other heart diseases, cerebrovascular diseases, or other vascular diseases were observed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the National Cancer Institute
volume
97
issue
21
pages
1609 - 1610
publisher
Oxford University Press
external identifiers
  • wos:000233117600012
  • pmid:16264181
  • scopus:27944460410
ISSN
1460-2105
DOI
10.1093/jnci/dji342
language
English
LU publication?
yes
id
798c4479-eeca-40ab-ba17-a3c5cfbff08a (old id 213816)
date added to LUP
2007-08-07 16:52:47
date last changed
2017-07-23 04:36:08
@article{798c4479-eeca-40ab-ba17-a3c5cfbff08a,
  abstract     = {From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years of adjuvant tamoxifen therapy with that in patients receiving 5 years of adjuvant tamoxifen therapy, 4175 of whom were recurrence free after 2 years of tamoxifen therapy. Among the 2046 patients randomly assigned to the 5-year group all-cause mortality, breast cancer-specific mortality, and the incidence of contralateral breast cancer were reduced, compared with those among 2129 patients randomized in the 2-year group, but the incidence of endometrial cancer was increased. In addition, mortality from coronary heart disease was statistically significantly reduced in the 5-year group, compared with that in the 2-year group (hazard ratio = 0.67, 95% confidence interval = 0.47 to 0.94; P = .022 [two-sided Wald test]). Ten years after surgery, 2.1% of the patients in the 5-year group and 3.5% of those in the 2-year group a died from coronary heart disease. No statistically significant increases in mortality from other heart diseases, cerebrovascular diseases, or other vascular diseases were observed.},
  author       = {Nordenskjold, B and Rosell, J and Rutqvist, L E and Malmström, Per and Bergh, J and Bengtsson, N O and Hatschek, T and Wallgren, A and Carstensen, J},
  issn         = {1460-2105},
  language     = {eng},
  number       = {21},
  pages        = {1609--1610},
  publisher    = {Oxford University Press},
  series       = {Journal of the National Cancer Institute},
  title        = {Coronary heart disease mortality after 5 years of adjuvant tamoxifen therapy: Results from a randomized trial},
  url          = {http://dx.doi.org/10.1093/jnci/dji342},
  volume       = {97},
  year         = {2005},
}