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Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation

Peccatori, J; Barkholt, L; Demirer, T; Sormani, MP; Bruzzi, P; Ciceri, F; Zambelli, A; Da Prada, GA; Pedrazzoli, P and Siena, S, et al. (2005) In Cancer 104(10). p.2099-2103
Abstract
BACKGROUND. The objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy. METHODS. The authors Studied 70 patients with advanced RCC Who underwent allogeneic transplantation with a fludarabine-based, reduced-intensity regimen. Ten parameters were analyzed at the time of transplantation for their power to predict Survival. Clinical features were examined first univariately; then, variables that were correlated significantly with Survival in the univariate analysis were included in a multivariate Cox regression model. RESULTS. Factors that were found to be associated... (More)
BACKGROUND. The objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy. METHODS. The authors Studied 70 patients with advanced RCC Who underwent allogeneic transplantation with a fludarabine-based, reduced-intensity regimen. Ten parameters were analyzed at the time of transplantation for their power to predict Survival. Clinical features were examined first univariately; then, variables that were correlated significantly with Survival in the univariate analysis were included in a multivariate Cox regression model. RESULTS. Factors that were found to be associated significantly with limited survival were performance Status, the number of metastatic sites, the presence of mediastinal metastasis, hemoglobin level, C-reactive protein (CRP) level, lactate dehydrogenase (LDH) level, and neutrophil counts. All these variables were included in a multivariate Cox regression model, and three were retained in the final model. Patients were classified according to the score estimated by the final Cox model in two groups (above or below the median Value): The median Survival was 3.5 months for patients who had a poor prognosis patients versus 23 months for patients who had a good prognosis. CONCLUSIONS. The Current findings suggested that three easily available parameters (performance status, CRP level, and LDH level) could be used to stratify patients with advanced RCC who are candidates for allografting and to assist clinicians in decision-making and selection of an appropriate treatment program. (Less)
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published
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keywords
transplantation, allogeneic stem cell, C-reactive protein, renal cell carcinoma, prognostic factors
in
Cancer
volume
104
issue
10
pages
2099 - 2103
publisher
John Wiley & Sons
external identifiers
  • wos:000233103000008
  • pmid:16220555
  • scopus:27644452675
ISSN
1097-0142
DOI
10.1002/cncr.21477
language
English
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yes
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916ba0d6-e19b-49ab-8541-a7f68f7264cc (old id 213988)
date added to LUP
2007-08-22 14:37:42
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2017-10-22 03:45:58
@article{916ba0d6-e19b-49ab-8541-a7f68f7264cc,
  abstract     = {BACKGROUND. The objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy. METHODS. The authors Studied 70 patients with advanced RCC Who underwent allogeneic transplantation with a fludarabine-based, reduced-intensity regimen. Ten parameters were analyzed at the time of transplantation for their power to predict Survival. Clinical features were examined first univariately; then, variables that were correlated significantly with Survival in the univariate analysis were included in a multivariate Cox regression model. RESULTS. Factors that were found to be associated significantly with limited survival were performance Status, the number of metastatic sites, the presence of mediastinal metastasis, hemoglobin level, C-reactive protein (CRP) level, lactate dehydrogenase (LDH) level, and neutrophil counts. All these variables were included in a multivariate Cox regression model, and three were retained in the final model. Patients were classified according to the score estimated by the final Cox model in two groups (above or below the median Value): The median Survival was 3.5 months for patients who had a poor prognosis patients versus 23 months for patients who had a good prognosis. CONCLUSIONS. The Current findings suggested that three easily available parameters (performance status, CRP level, and LDH level) could be used to stratify patients with advanced RCC who are candidates for allografting and to assist clinicians in decision-making and selection of an appropriate treatment program.},
  author       = {Peccatori, J and Barkholt, L and Demirer, T and Sormani, MP and Bruzzi, P and Ciceri, F and Zambelli, A and Da Prada, GA and Pedrazzoli, P and Siena, S and Massenkeil, G and Martino, R and Lenhoff, Stig and Corradini, P and Rosti, G and Ringden, O and Bregni, M and Niederwieser, D},
  issn         = {1097-0142},
  keyword      = {transplantation,allogeneic stem cell,C-reactive protein,renal cell carcinoma,prognostic factors},
  language     = {eng},
  number       = {10},
  pages        = {2099--2103},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation},
  url          = {http://dx.doi.org/10.1002/cncr.21477},
  volume       = {104},
  year         = {2005},
}