Persistent itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium
(2004) In Vaccine 22(27-28). p.3698-3706- Abstract
- Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminium containing vaccines, usually with positive epicutaneous tests to aluminium. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomised active surveillance in 25,232 10-year-olds. Parental reports 6 months after vaccination with Duplex(R) or diTeBooster(R) were collected for 22,365 (88%) pupils in 851 schools. We identified 3-6 children per 10,000 with a local itching nodule persisting for at least 2 months. There were no significant differences between the vaccine groups. Contact allergy to aluminium was not detected. The findings support the use of the... (More)
- Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminium containing vaccines, usually with positive epicutaneous tests to aluminium. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomised active surveillance in 25,232 10-year-olds. Parental reports 6 months after vaccination with Duplex(R) or diTeBooster(R) were collected for 22,365 (88%) pupils in 851 schools. We identified 3-6 children per 10,000 with a local itching nodule persisting for at least 2 months. There were no significant differences between the vaccine groups. Contact allergy to aluminium was not detected. The findings support the use of the vaccine presently available in the Swedish vaccination program. Continued surveillance of persistent itching nodules and aluminium contact allergy is, however, warranted for vaccines containing pertussis toxoid and aluminium. (C) 2004 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/898410
- author
- Netterlid, E ; Bruze, A ; Hindsen, A ; Isaksson, Marléne LU and Olin, P
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DT-vaccine booster, allergy, persistent local reactions, aluminium contact
- in
- Vaccine
- volume
- 22
- issue
- 27-28
- pages
- 3698 - 3706
- publisher
- Elsevier
- external identifiers
-
- wos:000223815100019
- pmid:15315849
- scopus:4143069191
- pmid:15315849
- ISSN
- 1873-2518
- DOI
- 10.1016/j.vaccine.2004.03.036
- language
- English
- LU publication?
- yes
- id
- 213ea2b9-f6e6-4c41-8bb6-43619529b815 (old id 898410)
- date added to LUP
- 2016-04-01 12:31:35
- date last changed
- 2022-02-26 08:16:49
@article{213ea2b9-f6e6-4c41-8bb6-43619529b815,
abstract = {{Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminium containing vaccines, usually with positive epicutaneous tests to aluminium. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomised active surveillance in 25,232 10-year-olds. Parental reports 6 months after vaccination with Duplex(R) or diTeBooster(R) were collected for 22,365 (88%) pupils in 851 schools. We identified 3-6 children per 10,000 with a local itching nodule persisting for at least 2 months. There were no significant differences between the vaccine groups. Contact allergy to aluminium was not detected. The findings support the use of the vaccine presently available in the Swedish vaccination program. Continued surveillance of persistent itching nodules and aluminium contact allergy is, however, warranted for vaccines containing pertussis toxoid and aluminium. (C) 2004 Elsevier Ltd. All rights reserved.}},
author = {{Netterlid, E and Bruze, A and Hindsen, A and Isaksson, Marléne and Olin, P}},
issn = {{1873-2518}},
keywords = {{DT-vaccine booster; allergy; persistent local reactions; aluminium contact}},
language = {{eng}},
number = {{27-28}},
pages = {{3698--3706}},
publisher = {{Elsevier}},
series = {{Vaccine}},
title = {{Persistent itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium}},
url = {{http://dx.doi.org/10.1016/j.vaccine.2004.03.036}},
doi = {{10.1016/j.vaccine.2004.03.036}},
volume = {{22}},
year = {{2004}},
}