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New topics in bradykinin research.

Maurer, M; Bader, M; Bas, M; Bossi, F; Cicardi, M; Cugno, M; Howarth, P; Kaplan, A; Kojda, G and Leeb-Lundberg, Fredrik LU , et al. (2011) In Allergy 66. p.1397-1406
Abstract
To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb-Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02686.x ABSTRACT: Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic,... (More)
To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb-Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02686.x ABSTRACT: Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target. (Less)
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Allergy
volume
66
pages
1397 - 1406
publisher
Wiley-Blackwell
external identifiers
  • WOS:000296046100001
  • PMID:21859431
  • Scopus:84860389162
ISSN
1398-9995
DOI
10.1111/j.1398-9995.2011.02686.x
language
English
LU publication?
yes
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cd695566-797e-4c95-8510-bb9e51711fb5 (old id 2150789)
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http://www.ncbi.nlm.nih.gov/pubmed/21859431?dopt=Abstract
date added to LUP
2011-09-04 13:27:10
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2017-01-22 04:21:02
@article{cd695566-797e-4c95-8510-bb9e51711fb5,
  abstract     = {To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb-Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02686.x ABSTRACT: Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.},
  author       = {Maurer, M and Bader, M and Bas, M and Bossi, F and Cicardi, M and Cugno, M and Howarth, P and Kaplan, A and Kojda, G and Leeb-Lundberg, Fredrik and Lötvall, J and Magerl, M},
  issn         = {1398-9995},
  language     = {eng},
  pages        = {1397--1406},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {New topics in bradykinin research.},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2011.02686.x},
  volume       = {66},
  year         = {2011},
}