Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.
(2011) In British Journal of Haematology 155. p.244-247- Abstract
- This study explored the feasibility and toxicity of individualized toxicity-titrated 6-mercaptopurine (6MP) dose increments during post-remission treatment with High-dose methotrexate (HDM) (5000 mg/m(2) , ×3) in 38 patients with Childhood (ALL). Patients were increased in steps of 25 mg 6MP/m(2) per day if they did not develop myelotoxicity within 2 weeks after HDM. 6MP could be increased in 31 patients (81%). Toxicity was acceptable and did not differ significantly between groups. Patients receiving 75 mg/m(2) per day had significantly shorter duration of treatment interruptions of 6MP than the remaining patients (P = 0·03). This study shows individualized toxicity-titrated 6MP dosing during consolidation is feasible without increased... (More)
- This study explored the feasibility and toxicity of individualized toxicity-titrated 6-mercaptopurine (6MP) dose increments during post-remission treatment with High-dose methotrexate (HDM) (5000 mg/m(2) , ×3) in 38 patients with Childhood (ALL). Patients were increased in steps of 25 mg 6MP/m(2) per day if they did not develop myelotoxicity within 2 weeks after HDM. 6MP could be increased in 31 patients (81%). Toxicity was acceptable and did not differ significantly between groups. Patients receiving 75 mg/m(2) per day had significantly shorter duration of treatment interruptions of 6MP than the remaining patients (P = 0·03). This study shows individualized toxicity-titrated 6MP dosing during consolidation is feasible without increased risk of toxicity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2150979
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Haematology
- volume
- 155
- pages
- 244 - 247
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000296063400010
- pmid:21848519
- scopus:80053567424
- pmid:21848519
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2011.08835.x
- language
- English
- LU publication?
- yes
- id
- 3523f873-6333-416d-8aaa-601a912b2071 (old id 2150979)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21848519?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:06
- date last changed
- 2024-06-08 05:35:38
@article{3523f873-6333-416d-8aaa-601a912b2071, abstract = {{This study explored the feasibility and toxicity of individualized toxicity-titrated 6-mercaptopurine (6MP) dose increments during post-remission treatment with High-dose methotrexate (HDM) (5000 mg/m(2) , ×3) in 38 patients with Childhood (ALL). Patients were increased in steps of 25 mg 6MP/m(2) per day if they did not develop myelotoxicity within 2 weeks after HDM. 6MP could be increased in 31 patients (81%). Toxicity was acceptable and did not differ significantly between groups. Patients receiving 75 mg/m(2) per day had significantly shorter duration of treatment interruptions of 6MP than the remaining patients (P = 0·03). This study shows individualized toxicity-titrated 6MP dosing during consolidation is feasible without increased risk of toxicity.}}, author = {{Frandsen, Thomas L and Abrahamsson, Jonas and Lausen, Birgitte and Vettenranta, Kim and Heyman, Mats and Behrentz, Michael and Castor, Anders and Wehner, Peder S and Frost, Britt-Marie and Andersen, Elisabeth W and Schmiegelow, Kjeld}}, issn = {{0007-1048}}, language = {{eng}}, pages = {{244--247}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2011.08835.x}}, doi = {{10.1111/j.1365-2141.2011.08835.x}}, volume = {{155}}, year = {{2011}}, }