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Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.

Frandsen, Thomas L ; Abrahamsson, Jonas ; Lausen, Birgitte ; Vettenranta, Kim ; Heyman, Mats ; Behrentz, Michael ; Castor, Anders LU ; Wehner, Peder S ; Frost, Britt-Marie and Andersen, Elisabeth W , et al. (2011) In British Journal of Haematology 155. p.244-247
Abstract
This study explored the feasibility and toxicity of individualized toxicity-titrated 6-mercaptopurine (6MP) dose increments during post-remission treatment with High-dose methotrexate (HDM) (5000 mg/m(2) , ×3) in 38 patients with Childhood (ALL). Patients were increased in steps of 25 mg 6MP/m(2) per day if they did not develop myelotoxicity within 2 weeks after HDM. 6MP could be increased in 31 patients (81%). Toxicity was acceptable and did not differ significantly between groups. Patients receiving 75 mg/m(2) per day had significantly shorter duration of treatment interruptions of 6MP than the remaining patients (P = 0·03). This study shows individualized toxicity-titrated 6MP dosing during consolidation is feasible without increased... (More)
This study explored the feasibility and toxicity of individualized toxicity-titrated 6-mercaptopurine (6MP) dose increments during post-remission treatment with High-dose methotrexate (HDM) (5000 mg/m(2) , ×3) in 38 patients with Childhood (ALL). Patients were increased in steps of 25 mg 6MP/m(2) per day if they did not develop myelotoxicity within 2 weeks after HDM. 6MP could be increased in 31 patients (81%). Toxicity was acceptable and did not differ significantly between groups. Patients receiving 75 mg/m(2) per day had significantly shorter duration of treatment interruptions of 6MP than the remaining patients (P = 0·03). This study shows individualized toxicity-titrated 6MP dosing during consolidation is feasible without increased risk of toxicity. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Haematology
volume
155
pages
244 - 247
publisher
Wiley-Blackwell
external identifiers
  • wos:000296063400010
  • pmid:21848519
  • scopus:80053567424
  • pmid:21848519
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2011.08835.x
language
English
LU publication?
yes
id
3523f873-6333-416d-8aaa-601a912b2071 (old id 2150979)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21848519?dopt=Abstract
date added to LUP
2016-04-04 08:54:06
date last changed
2022-01-29 07:28:07
@article{3523f873-6333-416d-8aaa-601a912b2071,
  abstract     = {{This study explored the feasibility and toxicity of individualized toxicity-titrated 6-mercaptopurine (6MP) dose increments during post-remission treatment with High-dose methotrexate (HDM) (5000 mg/m(2) , ×3) in 38 patients with Childhood (ALL). Patients were increased in steps of 25 mg 6MP/m(2) per day if they did not develop myelotoxicity within 2 weeks after HDM. 6MP could be increased in 31 patients (81%). Toxicity was acceptable and did not differ significantly between groups. Patients receiving 75 mg/m(2) per day had significantly shorter duration of treatment interruptions of 6MP than the remaining patients (P = 0·03). This study shows individualized toxicity-titrated 6MP dosing during consolidation is feasible without increased risk of toxicity.}},
  author       = {{Frandsen, Thomas L and Abrahamsson, Jonas and Lausen, Birgitte and Vettenranta, Kim and Heyman, Mats and Behrentz, Michael and Castor, Anders and Wehner, Peder S and Frost, Britt-Marie and Andersen, Elisabeth W and Schmiegelow, Kjeld}},
  issn         = {{0007-1048}},
  language     = {{eng}},
  pages        = {{244--247}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2141.2011.08835.x}},
  doi          = {{10.1111/j.1365-2141.2011.08835.x}},
  volume       = {{155}},
  year         = {{2011}},
}