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Placental ischemia and changes in umbilical and uteroplacental arterial and venous hemodynamics.

Thuring, Ann LU ; Marsal, Karel LU and Laurini, Ricardo LU (2012) In Journal of Maternal-Fetal & Neonatal Medicine 25. p.750-755
Abstract
Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially for signs of ischemia and inflammation. Results: All fetuses in uncomplicated pregnancies had normal flow velocity waveforms in umbilical artery; in the high-risk group, 18 fetuses had abnormal flow (increased PI or absent/reverse end-diastolic flow). The latter group had more often high ischemic score and infarctions in the placenta than found in... (More)
Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially for signs of ischemia and inflammation. Results: All fetuses in uncomplicated pregnancies had normal flow velocity waveforms in umbilical artery; in the high-risk group, 18 fetuses had abnormal flow (increased PI or absent/reverse end-diastolic flow). The latter group had more often high ischemic score and infarctions in the placenta than found in pregnancies with normal umbilical artery flow (p < 0.001 and p = 0.02, respectively). Similarly, the abnormal uterine artery flow pattern (uterine artery score 3-4) occurred more often with high ischemic score and placenta infarctions (p < 0.001 and p < 0.001, respectively). No significant associations were found between the uterine venous flow type and placental ischemia. Conclusion: Placental ischemic morphological changes were associated with Doppler ultrasound signs of increased resistance to arterial blood flow, both on the fetal and maternal sides of the placenta. No significant relation to the uterine venous flow velocities was found. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Maternal-Fetal & Neonatal Medicine
volume
25
pages
750 - 755
publisher
Taylor & Francis
external identifiers
  • wos:000304097600040
  • pmid:21827369
  • scopus:84861037902
ISSN
1476-7058
DOI
10.3109/14767058.2011.594466
language
English
LU publication?
yes
id
3df402b6-bf62-437d-b44b-4e9ebdd79f4b (old id 2151267)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21827369?dopt=Abstract
date added to LUP
2011-09-04 15:30:06
date last changed
2017-01-01 04:16:20
@article{3df402b6-bf62-437d-b44b-4e9ebdd79f4b,
  abstract     = {Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially for signs of ischemia and inflammation. Results: All fetuses in uncomplicated pregnancies had normal flow velocity waveforms in umbilical artery; in the high-risk group, 18 fetuses had abnormal flow (increased PI or absent/reverse end-diastolic flow). The latter group had more often high ischemic score and infarctions in the placenta than found in pregnancies with normal umbilical artery flow (p &lt; 0.001 and p = 0.02, respectively). Similarly, the abnormal uterine artery flow pattern (uterine artery score 3-4) occurred more often with high ischemic score and placenta infarctions (p &lt; 0.001 and p &lt; 0.001, respectively). No significant associations were found between the uterine venous flow type and placental ischemia. Conclusion: Placental ischemic morphological changes were associated with Doppler ultrasound signs of increased resistance to arterial blood flow, both on the fetal and maternal sides of the placenta. No significant relation to the uterine venous flow velocities was found.},
  author       = {Thuring, Ann and Marsal, Karel and Laurini, Ricardo},
  issn         = {1476-7058},
  language     = {eng},
  pages        = {750--755},
  publisher    = {Taylor & Francis},
  series       = {Journal of Maternal-Fetal & Neonatal Medicine},
  title        = {Placental ischemia and changes in umbilical and uteroplacental arterial and venous hemodynamics.},
  url          = {http://dx.doi.org/10.3109/14767058.2011.594466},
  volume       = {25},
  year         = {2012},
}