Placental ischemia and changes in umbilical and uteroplacental arterial and venous hemodynamics.
(2012) In Journal of Maternal-Fetal & Neonatal Medicine 25. p.750-755- Abstract
- Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially for signs of ischemia and inflammation. Results: All fetuses in uncomplicated pregnancies had normal flow velocity waveforms in umbilical artery; in the high-risk group, 18 fetuses had abnormal flow (increased PI or absent/reverse end-diastolic flow). The latter group had more often high ischemic score and infarctions in the placenta than found in... (More)
- Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially for signs of ischemia and inflammation. Results: All fetuses in uncomplicated pregnancies had normal flow velocity waveforms in umbilical artery; in the high-risk group, 18 fetuses had abnormal flow (increased PI or absent/reverse end-diastolic flow). The latter group had more often high ischemic score and infarctions in the placenta than found in pregnancies with normal umbilical artery flow (p < 0.001 and p = 0.02, respectively). Similarly, the abnormal uterine artery flow pattern (uterine artery score 3-4) occurred more often with high ischemic score and placenta infarctions (p < 0.001 and p < 0.001, respectively). No significant associations were found between the uterine venous flow type and placental ischemia. Conclusion: Placental ischemic morphological changes were associated with Doppler ultrasound signs of increased resistance to arterial blood flow, both on the fetal and maternal sides of the placenta. No significant relation to the uterine venous flow velocities was found. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151267
- author
- Thuring, Ann LU ; Marsal, Karel LU and Laurini, Ricardo LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Maternal-Fetal & Neonatal Medicine
- volume
- 25
- pages
- 750 - 755
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000304097600040
- pmid:21827369
- scopus:84861037902
- pmid:21827369
- ISSN
- 1476-7058
- DOI
- 10.3109/14767058.2011.594466
- language
- English
- LU publication?
- yes
- id
- 3df402b6-bf62-437d-b44b-4e9ebdd79f4b (old id 2151267)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21827369?dopt=Abstract
- date added to LUP
- 2016-04-01 11:13:35
- date last changed
- 2022-01-26 06:18:49
@article{3df402b6-bf62-437d-b44b-4e9ebdd79f4b,
abstract = {{Objective: To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. Material and methods: In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especially for signs of ischemia and inflammation. Results: All fetuses in uncomplicated pregnancies had normal flow velocity waveforms in umbilical artery; in the high-risk group, 18 fetuses had abnormal flow (increased PI or absent/reverse end-diastolic flow). The latter group had more often high ischemic score and infarctions in the placenta than found in pregnancies with normal umbilical artery flow (p < 0.001 and p = 0.02, respectively). Similarly, the abnormal uterine artery flow pattern (uterine artery score 3-4) occurred more often with high ischemic score and placenta infarctions (p < 0.001 and p < 0.001, respectively). No significant associations were found between the uterine venous flow type and placental ischemia. Conclusion: Placental ischemic morphological changes were associated with Doppler ultrasound signs of increased resistance to arterial blood flow, both on the fetal and maternal sides of the placenta. No significant relation to the uterine venous flow velocities was found.}},
author = {{Thuring, Ann and Marsal, Karel and Laurini, Ricardo}},
issn = {{1476-7058}},
language = {{eng}},
pages = {{750--755}},
publisher = {{Taylor & Francis}},
series = {{Journal of Maternal-Fetal & Neonatal Medicine}},
title = {{Placental ischemia and changes in umbilical and uteroplacental arterial and venous hemodynamics.}},
url = {{https://lup.lub.lu.se/search/files/2487229/2342496.pdf}},
doi = {{10.3109/14767058.2011.594466}},
volume = {{25}},
year = {{2012}},
}