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Lung function in children born after foetal growth restriction and very preterm birth

Morsing, Eva LU ; Gustafsson, Per and Brodszki, Jana LU (2012) In Acta paediatrica (Oslo, Norway : 1992) 101(1). p.48-54
Abstract
Aims: To assess lung function at early school age in children delivered at very early gestation owing to intrauterine growth restriction and abnormal foetal blood flow (IUGR). Methods:  Spirometry was performed at median age 8.4 (range 6.5-10.7) years in 31 children born preterm with IUGR (PT-IUGR) with a median (range) birth weight (BW) of 650 (395-976) g and median (range) gestational age 27 (24-29) weeks. Control groups were matched for gender and age and had BW appropriate for gestational age (AGA); 31 children born preterm (PT-AGA) with BW of 1010 (660-1790) g matched for gestational age at birth, and 31 children born at term (T-AGA) with BW of 3530 (3000-4390) g. Results:  The PT-IUGR group had lower mean (SD) values of z-scores for... (More)
Aims: To assess lung function at early school age in children delivered at very early gestation owing to intrauterine growth restriction and abnormal foetal blood flow (IUGR). Methods:  Spirometry was performed at median age 8.4 (range 6.5-10.7) years in 31 children born preterm with IUGR (PT-IUGR) with a median (range) birth weight (BW) of 650 (395-976) g and median (range) gestational age 27 (24-29) weeks. Control groups were matched for gender and age and had BW appropriate for gestational age (AGA); 31 children born preterm (PT-AGA) with BW of 1010 (660-1790) g matched for gestational age at birth, and 31 children born at term (T-AGA) with BW of 3530 (3000-4390) g. Results:  The PT-IUGR group had lower mean (SD) values of z-scores for FEV(1) , FEV(1) /FVC and forced mid-expiratory flow rate (FEF(25-75%) ) compared to the T-AGA group, p = 0.003, p = 0.032 and p < 0.001, respectively, but did not differ from the PT-AGA group. PT-IUGR children delivered at ≥26 gestational weeks (GW) had lower FEF(25-75%) than PT-AGA children of corresponding GA, p = 0.014. Conclusion:  Lung function was reduced in the PT-IUGR group at early school age compared to controls born at term. The influence of IUGR on later lung function was only apparent in children born preterm after 26 GW. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta paediatrica (Oslo, Norway : 1992)
volume
101
issue
1
pages
48 - 54
publisher
Taylor & Francis
external identifiers
  • pmid:21824191
  • wos:000297630000021
  • scopus:82955187329
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2011.02435.x
language
English
LU publication?
yes
id
1f491385-dcd7-4439-b839-066865fd8f6b (old id 2151329)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21824191?dopt=Abstract
date added to LUP
2011-09-04 21:27:47
date last changed
2017-09-17 08:45:43
@article{1f491385-dcd7-4439-b839-066865fd8f6b,
  abstract     = {Aims: To assess lung function at early school age in children delivered at very early gestation owing to intrauterine growth restriction and abnormal foetal blood flow (IUGR). Methods:  Spirometry was performed at median age 8.4 (range 6.5-10.7) years in 31 children born preterm with IUGR (PT-IUGR) with a median (range) birth weight (BW) of 650 (395-976) g and median (range) gestational age 27 (24-29) weeks. Control groups were matched for gender and age and had BW appropriate for gestational age (AGA); 31 children born preterm (PT-AGA) with BW of 1010 (660-1790) g matched for gestational age at birth, and 31 children born at term (T-AGA) with BW of 3530 (3000-4390) g. Results:  The PT-IUGR group had lower mean (SD) values of z-scores for FEV(1) , FEV(1) /FVC and forced mid-expiratory flow rate (FEF(25-75%) ) compared to the T-AGA group, p = 0.003, p = 0.032 and p &lt; 0.001, respectively, but did not differ from the PT-AGA group. PT-IUGR children delivered at ≥26 gestational weeks (GW) had lower FEF(25-75%) than PT-AGA children of corresponding GA, p = 0.014. Conclusion:  Lung function was reduced in the PT-IUGR group at early school age compared to controls born at term. The influence of IUGR on later lung function was only apparent in children born preterm after 26 GW.},
  author       = {Morsing, Eva and Gustafsson, Per and Brodszki, Jana},
  issn         = {1651-2227},
  language     = {eng},
  number       = {1},
  pages        = {48--54},
  publisher    = {Taylor & Francis},
  series       = {Acta paediatrica (Oslo, Norway : 1992)},
  title        = {Lung function in children born after foetal growth restriction and very preterm birth},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2011.02435.x},
  volume       = {101},
  year         = {2012},
}