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C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2011) In Clinical Biochemistry 44. p.1205-1208
Abstract
BACKGROUND: Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness. METHODS: We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time. RESULTS: Patients with AD showed overall lower CRP levels than other patients with mental illness, but elevated CRP levels in these patients were associated with lower cognitive function and shorter survival time. CONCLUSION: The reason for an overall low CRP level is not obvious. Elevated CRP level in patients with AD suggests the presence of inflammatory activity in this subgroup... (More)
BACKGROUND: Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness. METHODS: We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time. RESULTS: Patients with AD showed overall lower CRP levels than other patients with mental illness, but elevated CRP levels in these patients were associated with lower cognitive function and shorter survival time. CONCLUSION: The reason for an overall low CRP level is not obvious. Elevated CRP level in patients with AD suggests the presence of inflammatory activity in this subgroup of patients that may benefit from anti-inflammatory administration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
44
pages
1205 - 1208
publisher
Elsevier
external identifiers
  • wos:000295424500003
  • pmid:21819975
  • scopus:80052917519
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2011.07.011
language
English
LU publication?
yes
id
0a91c1f1-07be-4a58-93e8-8fbf63623cf6 (old id 2151372)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21819975?dopt=Abstract
date added to LUP
2011-09-04 16:07:17
date last changed
2017-11-19 04:17:49
@article{0a91c1f1-07be-4a58-93e8-8fbf63623cf6,
  abstract     = {BACKGROUND: Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness. METHODS: We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time. RESULTS: Patients with AD showed overall lower CRP levels than other patients with mental illness, but elevated CRP levels in these patients were associated with lower cognitive function and shorter survival time. CONCLUSION: The reason for an overall low CRP level is not obvious. Elevated CRP level in patients with AD suggests the presence of inflammatory activity in this subgroup of patients that may benefit from anti-inflammatory administration.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1873-2933},
  language     = {eng},
  pages        = {1205--1208},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2011.07.011},
  volume       = {44},
  year         = {2011},
}